Clinical care Bundles for Adult Meningitis in Malawi

Not Applicable

Completed

• Conditions: Bacterial meningitis; Nervous System Diseases; Bacterial meningitis, not elsewhere classified

• Registration Number: ISRCTN96218197
• Lead Sponsor: iverpool School of Tropical Medicine (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11-17
• Last Update Posted: 20 November 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Screening inclusion criteria
1. 1. All adults > 12 years presenting to the adult emergency trauma centre with fever plus one of headache/convulsions/confusion/neck stiffness (Note: In Malawi the cut off for paediatric medicine is <12 years and all admissions over this age are referred to the adult service)
2. Final inclusion criteria
2.1. Cerebrospinal fluid (CSF) white cell count of >50 cells/mm2, irrespective of human immunodeficiency virus (HIV) status, or visible bacteria in the counting chamber

Exclusion Criteria

1. Screening exclusion criteria
1.1. Known terminal disease
1.2. Head injury
1.3. Proven cerebral malaria
2. Final exclusion criteria
2.1. CSF culture, antigen test or stain for fungal or mycobacterial organisms, or CSF <100 cells/mm3 HIV negative or CSF <5 cells/mm3 HIV positive, or a CSF WCC <50% neutrophils

Study & Design

• Study Type: Observational
• Study Design: Not specified