Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Primary Hyperlipidemia or Mixed Dyslipidemia At Risk Of Cardiovascular Events
- Conditions
- Hyperlipidemia
- Interventions
- Other: Placebo
- Registration Number
- NCT02100514
- Lead Sponsor
- Pfizer
- Brief Summary
This study is a multicenter, double-blind, randomized study to access the efficacy, safety and tolerability of Bococizumab (PF-04950615; RN316) in subjects with hyperlipidemia receiving background statin therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 746
- Treated with a statin
- Fasting LDL-C >=100 mg/dL and triglyceride <= 400 mg/dL
- High or very high risk of incurring a cardiovascular event
- Pregnant or breastfeeding females
- Cardiovascular or cerebrovascular event or procedure within 90 days
- Congestive heart failure NYHA class IV
- Poorly controlled hypertension
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo Placebo - Bococizumab (PF-04950615; RN316) Bococizumab (PF-04950615; RN316) Bococizumab (PF-04950615; RN316)
- Primary Outcome Measures
Name Time Method Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 12 Baseline, Week 12
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Fasting Low Density Lipoprotein Cholesterol (LDL-C) Less Than or Equal to (<=) 70 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Week 12, 24, 52 Percent Change From Baseline in Fasting Total Cholesterol (TC) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Apolipoprotein B (ApoB) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Non High Density Lipoprotein Cholesterol (Non HDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Less Than (<) 200 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Greater Than or Equal to (>=) 200 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Lipoprotein (A) (Lp[A]) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting High Density Lipoprotein Cholesterol (HDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 24, 52: Treatment Period Baseline, Week 24, 52 Percent Change From Baseline in Fasting Triglycerides (TG) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Apolipoprotein A-I (ApoA-I) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Apolipoprotein A-II (ApoA-II) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percent Change From Baseline in Fasting Very Low Density Lipoprotein Cholesterol (VLDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Absolute Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Less Than (<) 200 Milligram Per Deciliter (mg/dL) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) by Triglycerides Cut-off of Greater Than or Equal to (>=) 200 Milligram Per Deciliter (mg/dL) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Total Cholesterol (TC) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Non High Density Lipoprotein Cholesterol (Non HDL-C) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Apolipoprotein B (ApoB) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting Lipoprotein (A) (Lp[A]) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Fasting High Density Lipoprotein Cholesterol (HDL-C) at Week 12 Baseline, Week 12 Absolute Change From Baseline in Ratio of Fasting Total Cholesterol (TC) to High Density Lipoprotein Cholesterol (HDL-C) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Absolute Change From Baseline in Ratio of Fasting Apolipoprotein B (ApoB) to Apolipoprotein A-I (ApoA-I) at Week 12, 24 and 52 Baseline, Week 12, 24, 52 Percentage of Participants Achieving Fasting Low Density Lipoprotein Cholesterol (LDL-C) Less Than or Equal to (<=) 100 Milligram Per Deciliter (mg/dL) at Week 12, 24 and 52 Week 12, 24, 52 Plasma Concentration Versus Time Summary of PF-04950615 Week 12, 24, 52 Percentage of Participants With Adverse Events (AEs) Related to Type 1 and 3 Hypersensitivity Reactions and Injection Site Reactions Baseline up to end of study (up to 110 weeks) Type 1 hypersensitivity or allergic reactions were possible in response to any injected protein and included shortness of breath, urticaria, anaphylaxis and angioedema. Type 3 hypersensitivity reactions were similar to Type 1 hypersensitivity reactions but were likely to be delayed from the time of injection and included symptoms such as rash, urticaria, polyarthritis, myalgia's, polysynovitis, fever and if severe then included glomerulonephritis. Injection site reactions included injection site bruising, discolouration, erythema, haematoma, haemorrhage, nodule, induration, inflammation, mass, pain, paraesthesia, pruritus, swelling, vesicles, warmth, scab and rash. Participants with type 1 or type 3 hypersensitivity reactions and participants with injection site reactions were reported in this outcome measure.
Percentage of Participants With Anti-Drug Antibodies (ADA) and Neutralizing Antibodies (nAb): Treatment Period Baseline up to Week 58 Percentage of participants with at least 1 positive ADA titer or 1 positive nAb titer were reported. ADA titer \>=6.23 (log 2) unit was considered to be ADA positive and nAb titer \>=1.58 (log 2) unit was considered to be nAb positive.
Number of Participants Who Changed Concomitant Medication During Extension Period Week 58 follow-up to Week 110 In this outcome measure, total number of participants who changed their lipid-lowering medications or added a monoclonal antibody medication during the extension period were reported.
Percent Change From Baseline in Fasting Low Density Lipoprotein Cholesterol (LDL-C) at Week 58 (Follow up), 71, 84, 97 and 110: Extension Period Baseline, Week 58 (follow up), 71, 84, 97, 110 Percentage of Participants With Anti-Drug Antibodies (ADA) and Neutralizing Antibodies (nAb): Extension Period Week 58 (follow-up), Week 71, Week 84, Week 97, Week 110 Percentage of participants with at least 1 positive ADA titer or 1 positive nAb titer were reported. ADA titer \>=6.23 log2 unit was considered to be ADA positive and nAb titer \>=1.58 log2 unit was considered to be nAb positive.
Trial Locations
- Locations (214)
Manna Research Inc.
🇨🇦Toronto, Ontario, Canada
lntermed Group
🇺🇸Los Angeles, California, United States
American Institute of Research
🇺🇸Los Angeles, California, United States
Gulf Coast Medical Research,LLC
🇺🇸Houston, Texas, United States
Sunrise Research Institute, Inc
🇺🇸Miami, Florida, United States
Prestige Clinical Research Center, Inc.
🇺🇸Miami, Florida, United States
Northwest Family Physicians
🇺🇸Wichita, Kansas, United States
Heartland Research Associates, LLC
🇺🇸Wichita, Kansas, United States
Scarborough Cardiology Research
🇨🇦Scarborough, Ontario, Canada
Medisch Spectrum Twente
🇳🇱Enschede, Netherlands
Cardiocentrum Kladno s.r.o., Kardiologicka ambulance
🇨🇿Kladno, Czechia
Lekarna - P-P Klinika Kladno
🇨🇿Kladno, Czechia
SKDS Research Inc.
🇨🇦Newmarket, Ontario, Canada
Nemocnice Slany, Interni oddeleni
🇨🇿Slany, Czechia
Corunna Medical Research Centre
🇨🇦Corunna, Ontario, Canada
Etela-Karjalan Keskussairaala
🇫🇮Lappeenranta, Finland
Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada
Kardiologicka ambulance
🇨🇿Trutnov, Kralovehradecky KRAJ, Czechia
Lunacor s.r.o.
🇨🇿Kromeriz, Czechia
IKEM, Ustavni lekarna
🇨🇿Praha 4, Czechia
Andromed Eindhoven
🇳🇱Eindhoven, Netherlands
Beatrix Hospital
🇳🇱Gorinchem, Netherlands
Fakultni nemocnice u sv. Anny Brno. Oddeleni klinicke biochemie
🇨🇿Brno, Czechia
LMC Clinical Research Inc. (Etobicoke)
🇨🇦Etobicoke, Ontario, Canada
Sacred Heart Hospital-Hallym University
🇰🇷Anyang-si, Gyeonggi-do, Korea, Republic of
Lekarna 203-02
🇨🇿Slany, Czechia
Lekarna Domovina
🇨🇿Olomouc, Czechia
St Lucas Andreas Hospital
🇳🇱Amsterdam, North Holland, Netherlands
Fakultni Nemocnice Kralovske Vinohrady, II. interni klinika
🇨🇿Praha 10, Vinohrady, Czechia
Dr.Max lekarna
🇨🇿Trutnov, Czechia
Hanyang University Guri Hospital
🇰🇷Guri-si, Gyeonggi-do, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
AeskuLab k.s., Lipidova poradna
🇨🇿Teplice, Czechia
PreventaMed, s.r.o.
🇨🇿Olomouc, Czechia
Rouge Valley Health System - Centenary
🇨🇦Toronto, Ontario, Canada
Ecogene-21
🇨🇦Chicoutimi, Quebec, Canada
BENU lekarna
🇨🇿Pribram, Czechia
Fakultni nemocnice u sv. Anny. Nemoenicni lekarna (pharmacy)
🇨🇿Brno, Czechia
Fakultni Nemocnice Olomouc, III. interni klinika ¿ nefrologicka, revmatologicka a endokrinologicka
🇨🇿Olomouc, Czechia
Creekside Endocrine Associates, PC
🇺🇸Denver, Colorado, United States
South Oklahoma Heart Research, LLC
🇺🇸Oklahoma City, Oklahoma, United States
LMC Clinical Research Inc. (Oakville)
🇨🇦Oakville, Ontario, Canada
LMC Clinical Research Inc. (Markham)
🇨🇦Markham, Ontario, Canada
Kawartha Cardiology Clinical Trials
🇨🇦Peterborough, Ontario, Canada
LMC Clinical Research Inc. (Thornhill)
🇨🇦Thornhill, Ontario, Canada
The Office of Dr. James Cha
🇨🇦Oshawa, Ontario, Canada
LMC Clinical Research Inc. (Bayview)
🇨🇦Toronto, Ontario, Canada
Alpha Recherche Clinique
🇨🇦Quebec, Canada
ViaCar Recherche Clinique Inc.
🇨🇦Greenfield Park, Quebec, Canada
Centre de Depistage et de Recherche Cardiovasculaire Rive-Sud
🇨🇦Longueuil, Quebec, Canada
C.I.C. Maurice Inc.
🇨🇦Trois-Rivieres, Quebec, Canada
Centre De Sante Et De Services Sociaux De Beauce (CSSSB)
🇨🇦Saint-Georges, Beauce, Quebec, Canada
Clinique des maladies lipidiques de Quebec
🇨🇦Quebec, Canada
C.I.C. Mauricie Inc.
🇨🇦Trois-Rivieres, Quebec, Canada
Meridien Research
🇺🇸Tampa, Florida, United States
Bethesda Health Research
🇺🇸Bethesda, Maryland, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
IKEM, Oddeleni preventivni kardiologie
🇨🇿Praha 4, Czechia
Kardiologicka ambulance, III. Poliklinika
🇨🇿Pribram, Czechia
Lekarna Centrum (pharmacy)
🇨🇿Teplice, Czechia
Advanced Cardiovascular, LLC, Research
🇺🇸Auburn, Alabama, United States
Advanced Cardiovascular, LLC Research
🇺🇸Alexander City, Alabama, United States
Clinical Research Advantage, Inc./Family Practice Specialists, Ltd.
🇺🇸Phoenix, Arizona, United States
Radiant Research, Inc.
🇺🇸Santa Rosa, California, United States
Clinical Research Advantage, Inc./Family Practice Specialists, LTD
🇺🇸Phoenix, Arizona, United States
Radiant Research, Inc
🇺🇸Tucson, Arizona, United States
Lynn Institute of the Ozarks
🇺🇸Little Rock, Arkansas, United States
The Office of Larry Watkins, MD
🇺🇸Little Rock, Arkansas, United States
The Office of Lucita M. Cruz, M.D., Inc.
🇺🇸Norwalk, California, United States
IMD Medical Group
🇺🇸Los Angeles, California, United States
Orange County Research Center
🇺🇸Tustin, California, United States
Clinical Research Advantage, Inc. / Colorado Springs Family Practice
🇺🇸Colorado Springs, Colorado, United States
Ventura Clinical Trials
🇺🇸Ventura, California, United States
Boca Raton Clinical Research Associates
🇺🇸Boca Raton, Florida, United States
BRCR Medical Center, Inc.
🇺🇸Boca Raton, Florida, United States
Florida Health Center
🇺🇸Fort Lauderdale, Florida, United States
Linfritz Research Institute Inc.
🇺🇸Coral Gables, Florida, United States
Health Care Family Rehab & Research Center
🇺🇸Hialeah, Florida, United States
Precision Research Organization
🇺🇸Miami Lakes, Florida, United States
NewPhase Clinical Trials, Corp.
🇺🇸Miami Beach, Florida, United States
Elite Clinical Research
🇺🇸Miami, Florida, United States
Advanced Clinical Research of Miami
🇺🇸Miami, Florida, United States
The Research Specialists of Florida, Inc.
🇺🇸Miami, Florida, United States
Columbus Clinical Services, LLC
🇺🇸Miami, Florida, United States
American Family Medical
🇺🇸Ocala, Florida, United States
First Quality
🇺🇸Miramar, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
Andres Patron, D.O.P.A.
🇺🇸Pembroke Pines, Florida, United States
Pines Care Research Center, LLC
🇺🇸Pembroke Pines, Florida, United States
Progressive Medical Research
🇺🇸Port Orange, Florida, United States
DBC Research USA
🇺🇸Pembroke Pines, Florida, United States
Accord Clinical Research, Llc
🇺🇸Port Orange, Florida, United States
Northwest Clinical Trials, Inc.
🇺🇸Boise, Idaho, United States
American Health Network of Indiana, LLC
🇺🇸Avon, Indiana, United States
Cardiovascular Center of Sarasota
🇺🇸Sarasota, Florida, United States
East Coast Institute for Research, LLC/ Baker-Gilmour Cardiovascular Institute
🇺🇸Saint Augustine, Florida, United States
East Coast Institute for RSCH, St. Augustine Cardiology Associates, Research
🇺🇸Saint Augustine, Florida, United States
Imperial Health, LLP
🇺🇸Lake Charles, Louisiana, United States
Centennial Medical Group
🇺🇸Elkridge, Maryland, United States
Clinical Trials of America LA
🇺🇸Monroe, Louisiana, United States
McLaren Flint
🇺🇸Flint, Michigan, United States
CentraCare Heart & Vascular Center @ St. Cloud Hospital
🇺🇸Saint Cloud, Minnesota, United States
Riser Medical Research
🇺🇸Picayune, Mississippi, United States
Washington University, The Center for Advanced Medicine
🇺🇸Saint Louis, Missouri, United States
ActivMed Practices & Research, Inc.
🇺🇸Portsmouth, New Hampshire, United States
Clinical Research Advantage, Inc. (Prairie Fields Family Medicine, PC)
🇺🇸Fremont, Nebraska, United States
Physician's East Endocrinology
🇺🇸Greenville, North Carolina, United States
Physician's East P.A.
🇺🇸Greenville, North Carolina, United States
Catawba Valley Medical Group, Inc.
🇺🇸Hickory, North Carolina, United States
Wake Internal Medicine Consultants, Inc.
🇺🇸Raleigh, North Carolina, United States
PMG Research of Hickory
🇺🇸Hickory, North Carolina, United States
Office of Daniel G. Williams, MD
🇺🇸Perrysburg, Ohio, United States
Primed Clinical Research
🇺🇸Dayton, Ohio, United States
Castlerock Clinical Research Consultants,LLC
🇺🇸Tulsa, Oklahoma, United States
Harleysville Medical Associates
🇺🇸Harleysville, Pennsylvania, United States
Berks Cardiologists, Ltd.
🇺🇸Wyomissing, Pennsylvania, United States
Ellipsis Research Group, LLC
🇺🇸Columbia, South Carolina, United States
Spartanburg Medical Research
🇺🇸Spartanburg, South Carolina, United States
Stern Cardiovascular Foundation, Inc
🇺🇸Germantown, Tennessee, United States
Apex Cardiology
🇺🇸Jackson, Tennessee, United States
Research Associates of Jackson
🇺🇸Jackson, Tennessee, United States
PMG Research, Inc d/b/a PMG Research of Knoxville
🇺🇸Knoxville, Tennessee, United States
Juno Research, LLC
🇺🇸Katy, Texas, United States
Office of Michelle Zaniewski MD., PA.
🇺🇸Houston, Texas, United States
Millennium Clinical Trials, LLC
🇺🇸Arlington, Virginia, United States
Clinical Research Advantage, Inc./ Plano Internal Medicine Associates
🇺🇸Plano, Texas, United States
Clinical Trials of Texas, Inc.
🇺🇸San Antonio, Texas, United States
Aspen Clinical Research
🇺🇸Orem, Utah, United States
National Clinical Research-Norfolk, Inc.
🇺🇸Norfolk, Virginia, United States
Sound Health Care Center
🇺🇸Port Orchard, Washington, United States
Sound Medical Research
🇺🇸Port Orchard, Washington, United States
Walla Walla Clinic
🇺🇸Walla Walla, Washington, United States
HFM Heart and Vascular Center/Holy Family Memorial, Inc
🇺🇸Manitowoc, Wisconsin, United States
Office of Dr. Ronald Collette MD
🇨🇦Burnaby, British Columbia, Canada
Clinical Investigation Specialists, Inc.
🇺🇸Kenosha, Wisconsin, United States
Medical Arts Health Research Group
🇨🇦Kamloops, British Columbia, Canada
LMC Clinical Research Inc. (Calgary)
🇨🇦Calgary, Alberta, Canada
Glover Medical Clinic
🇨🇦Langley, British Columbia, Canada
LMC Clinical Research Inc. (Barrie)
🇨🇦Barrie, Ontario, Canada
Zuyderland Medisch Centrum
🇳🇱Heerlen, Netherlands
Ikazia Hospital
🇳🇱Rotterdam, Netherlands
LMC Clinical Research Inc. (Brampton)
🇨🇦Brampton, Ontario, Canada
Aggarwal And Associates Ltd
🇨🇦Brampton, Ontario, Canada
Lekarna Fakultni nemocnice Olomouc (pharmacy)
🇨🇿Olomouc, Czechia
Turku University Hospital
🇫🇮Turku, Finland
The Catholic University of Korea, Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Gelre Hospitals
🇳🇱Apeldoorn, Netherlands
Martini Ziekenhuis
🇳🇱Groningen, Netherlands
St. Elisabeth Hospital
🇳🇱Tilburg, Netherlands
Andro Medical Research B.V.
🇳🇱Rotterdam, Netherlands
Ossum Gronert Legetjeneste AS
🇳🇴Honefoss, Norway
Oslo Universitetssykehus HF
🇳🇴Oslo, Norway
Oslo Universitetssykehus HF, Ulleval
🇳🇴Oslo, Norway
KO-MED Centra Kliniczne Lublin
🇵🇱Lublin, Lubelskie, Poland
National University Hospital
🇸🇬Singapore, Singapore
KO-MED. Centra Kliniczne Staszow
🇵🇱Staszow, Swietokrzyskie, Poland
KO-MED Centra Kliniczne Zamosc
🇵🇱Zamosc, Lubelskie, Poland
MCBK Sc lwona Czajkowska Monika Barney
🇵🇱Grodzisk Mazowiecki, Poland
Synexus Polska Sp. z o. o. Oddizial w Katowicach.
🇵🇱Katowice, Poland
Clinport Tura Lipinska Dabrowski S.C.
🇵🇱Katowice, Poland
Krakowski Szpital Specjalistyczny im. Jana Pawla II
🇵🇱Krakow, Poland
Jan Zbigniew Peruga NZOZ SALUS
🇵🇱Lodz, Poland
Synexus Polska Sp. z o.o. Oddzial w Warszawie
🇵🇱Warszawa, Poland
KO-MED Centra Kliniczne Sp. z o.o.
🇵🇱Pulawy, Poland
Zespol Opieki Zdrowotnej W Olawie, Oddzial Chorob Wewnetrznych
🇵🇱Olawa, Poland
Synexus Polska Sp. z o.o Oddzial w Poznaniu
🇵🇱Poznan, Poland
Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
🇵🇱Wroclaw, Poland
.WroMedica Irena Bielicka, Janusz Szczepanik Spolka Cywlina
🇵🇱Wroclaw, Poland
Ponce School Of Medicine
🇵🇷Ponce, Puerto Rico
Cardiometabolic Research Center, Inc
🇵🇷Ponce, Puerto Rico
Caparra Internal Medicine
🇵🇷Rio Grande, Puerto Rico
National Heart Centre Singapore
🇸🇬Singapore, Singapore
Vardcentralen Lessebo
🇸🇪Lessebo, Sweden
Clinical Trial Center (CTC)/Centrum foer klinisk proevning
🇸🇪Goteborg, Sweden
Clinical Trials Consultants AB
🇸🇪Linkoping, Sweden
Capio Citykliniken Hjartmottagning
🇸🇪Lund, Sweden
ProbarE i Lund AB
🇸🇪Lund, Sweden
Citydiabetes
🇸🇪Stockholm, Sweden
Dalecarlia Clinical Research Center
🇸🇪Rattvik, Sweden
Karolinska Universitetssjukhuset Huddinge
🇸🇪Stockholm, Sweden
Synexus Thames Valley Clinical Research Centre
🇬🇧Reading, Berkshire, United Kingdom
Salford Royal NHS Foundation Trust
🇬🇧Salford, Greater Manchester, United Kingdom
Synexus Scotland Clinical Research Centre
🇬🇧Glasgow, Lanarkshire Scotland, United Kingdom
Synexus Midlands Clinical Research Centre
🇬🇧Birmingham, United Kingdom
Synexus Lancashire Clinical Research Centre
🇬🇧Chorley, Lancashire, United Kingdom
University Hospital Ayr - Nhs Ayrshire And Arran
🇬🇧Ayr, United Kingdom
Worcestershire Acute Hospitals NHS Trust - Worcestershire Royal Hospital
🇬🇧Worcester, Worcestershire, United Kingdom
Synexus North East Clinical Research Centre - Hexham General Hospital
🇬🇧Hexham, Northumberland, United Kingdom
Hull and East Yorkshire Hospitals NHS Trust
🇬🇧Hull, United Kingdom
Synexus Merseyside Clinical Research Centre
🇬🇧Liverpool, United Kingdom
Synexus Manchester Clinical Research Centre
🇬🇧Manchester, United Kingdom
Abertawe Bro Morgannwg University Local Health Board Joint Clinical Research Facility,
🇬🇧Swansea, United Kingdom
Wake Research Associates, LLC
🇺🇸Raleigh, North Carolina, United States
CentraCare Heart & Vascular Center at St. Cloud Hospital
🇺🇸Saint Cloud, Minnesota, United States
Suncoast Research Group, LLD
🇺🇸Miami, Florida, United States
Indago Research & Health Center, Inc.
🇺🇸Hialeah, Florida, United States
Panax Clinical Research
🇺🇸Miami Lakes, Florida, United States
Physician's East, PA
🇺🇸Greenville, North Carolina, United States
Crescent City Clinical Research Center, LLC
🇺🇸Metairie, Louisiana, United States
Clinical Trials of America, Inc.
🇺🇸Hickory, North Carolina, United States
Punzi Medical Center
🇺🇸Carrollton, Texas, United States
Gulf Coast Medical Research, LLC
🇺🇸Sugar Land, Texas, United States
Cook Street Medical Clinic
🇨🇦Victoria, British Columbia, Canada
Synexus Polska Sp. z o.o. Oddzial w Gdyni
🇵🇱Gdynia, Poland
The Office of James K. Lai, MD Inc.
🇨🇦Vancouver, British Columbia, Canada
University of Colorado Hospital
🇺🇸Aurora, Colorado, United States
D&A Research and Genetics
🇳🇱Sneek, Netherlands
The Medical Arts Health Research Group
🇨🇦Penticton, British Columbia, Canada
Fraser Clinical Trials
🇨🇦New Westminster, British Columbia, Canada
Superior Research, LLC
🇺🇸Sacramento, California, United States
Superior Research ,LLC
🇺🇸Sacramento, California, United States
Albuquerque Clinical Trials, Inc.
🇺🇸Albuquerque, New Mexico, United States
Medical Research South, LLC
🇺🇸Charleston, South Carolina, United States
University Medical Center Utrecht
🇳🇱Utrecht, Netherlands