Effects of GnRH Antagonist versus GnRH Agonist Protocol on ART outcomes in Poor ovarian Responders
Phase 2
- Conditions
- Poor ovarian Responders.Other ovarian dysfunction
- Registration Number
- IRCT201302271760N21
- Lead Sponsor
- Vice Chancellor for Research and Technology, Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
Infertile women who underwent IVF process and poor ovarian response; The number of oocytes recovered in less than 5; Serum estradiol levels on the day of HCG injection is less than pg / ml 600; Serum FSH levels in Male than 3 mIU / ml 12; Has over 37 years of age; Cessation of ovarian cycles due to poor response.
Exclusion criteria:
Chronic diseases; Diabetes; Any endocrine disease; Submucosal polyps; Leiomyoma and uterine septum.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pregnancy. Timepoint: 7-6 weeks to see the gestational sac. Method of measurement: Ultrasound.
- Secondary Outcome Measures
Name Time Method Endometrial thickness. Timepoint: Day of HCG injection. Method of measurement: Ultrasound.;Estradiol levels. Timepoint: Day of HCG injection. Method of measurement: Ultrasound.;The number of oocytes recovered. Timepoint: Day puncture. Method of measurement: Laboratory.;The duration of ovarian stimulation. Timepoint: Duration of drug use. Method of measurement: Clinical.;No. of fertilized oocytes. Timepoint: Day of embryo transfer. Method of measurement: Laboratory.;The amount of transferred embryos. Timepoint: Day of embryo transfer. Method of measurement: Laboratory.;The number of canceled cycles. Timepoint: Before embryo transfer. Method of measurement: Clinical.;Pregnancy than to transfer. Timepoint: 16 days after embryo transfer. Method of measurement: Laboratory.;The incidence of ovarian hyperstimulation syndrome (OHSS). Timepoint: After puncture. Method of measurement: Clinical & Laboratory.;The total amount of FSH. Timepoint: 48 hours before puncture. Method of measurement: Laboratory.