EFFECTIVENESS OF TRAMADOL AND KETAMINE AS ADJUVANTS TO BUPIVACAINE FOR INCISIONAL INFILTRATION FOR POSTOPERATIVE ANALGESIA FOLLOWING MAJOR ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- To Compare post operative pain score
研究概览
简要总结
Overnight fasting
All patient will be premedicated with Tab lorazepam (1 mg) at night before surgery.
Preoperative patient will be informed about Numeric Rating Scale for pain.
Local Infiltration at the end of surgery.
ØGroup-1 : Subcutaneous Tramadol 1mg/kg mixed with 0.25% of Bupivacaine 0.7mg/kg (diluted to 20ml with 0.9% NS) (N = 40)
ØGroup-2 : Subcutaneous Ketamine 1mg/kg mixed with 0.25% of Bupivacaine 0.7mg/kg (diluted to 20ml with 0.9% NS) (N = 40)
Standard monitor
Standard General Anaesthesia with proper size cuffed oral endotracheal tube.
Intra-Operative monitoring - HR, ECG, BP, SPO2, ETCO2, Urine output, Temperature
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Open abdomibal surgeries under general anaesthesia.
排除标准
- •Uncotrolled cardio respiratory disorders Altered hepatorenal function Refusal to participate Allergic to study drugs Psychological problems long term opioid users BMI more than 30 kilogram per meter square.
结局指标
主要结局
To Compare post operative pain score
时间窗: 0 hr, 2 hr, 4 hr, 6 hr, 12 hr, 18 hr, 24 hrs after Infiltration
次要结局
- To compare duration of analgesia(To compare post-operative rescue analgesic requirements)
研究者
Dr Darotikumari Sudhirbhai Patel
Gujarat cancer and Research institute,BJMC