Effect of Magnesium Sulphate and Ketamine Nebulization in preoperative period for prevention of postoperative Sore throat and other airway morbidities

Completed

Conditions: Medical and Surgical, Postoperative Sore Throat,

Registration Number: CTRI/2019/08/020785

Lead Sponsor: Department of Anesthesia

Brief Summary: A Prospective randomized double blind study titled â€œComparison of effect of Magnesium

Sulphate Nebulization and Ketamine nebulization in prevention of postoperative Sore throatâ€

was undertaken at M.S.Ramaiah Hospitals, Bangalore. The study was conducted on 111

patients belonging to ASA 1, 2 and 3 undergoing elective surgery under general anaesthesia

with tracheal intubation. Study subjects were divided into three study groups. Patients in

Group M were nebulized with 3ml (300mg) of Magnesium Sulphate, Group K with 3ml

(50mg) of Ketamine and Group S with 3ml Normal Saline. Nebulization was administered

15minutes prior to the surgery and general anaesthesia was induced 5minutes after

Nebulization. Hemodynamic monitoring was done pre nebulization, post nebulization and

post induction. Postoperatively patients were assessed for incidence and severity of POST,

hoarseness of voice, dysphagia and cough at intervals of 0, 2, 4, 12 and 24 hours

postoperatively.

The incidence of POST was significantly less in Group M (13.5%) and Group K (2.7%) when

compared to Group S (94.6%). There was also significant reduction in the incidence and

severity of Postoperative hoarseness, dysphagia and cough at 0, 2 and 4 hours in Group M

and Group K when compared to Group S.

Thus it can be concluded that Preoperative Nebulization with Magnesium sulphate 300mg or

Ketamine 50mg is an effective method for preventing Postoperative Sore throat,

hoarseness, dysphagia and cough in patients undergoing elective surgery under General

anaesthesia with tracheal intubation.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 111

Inclusion Criteria

Patients giving informed written consent 2.
ASA physical status I-III.
Malampati Grade I-II.
Patients scheduled for elective surgery under GA with Tracheal intubation.

Exclusion Criteria

Surgical procedures of >2hours(H) duration & ENT surgeries on the adenoids, Tonsils & Ear and Intra-Oral surgeries.
Prone positions or steep trendelenberg or Anti-Trendelenberg Position.
H/o URTI in the previous 2 weeks.
H/o Smoking .
H/o reactive airway disease & already on bronchodilator nebulization.
Endotracheal (ET) Tube cuff pressure >25 cmH2O in order to obtain airtight seal.
H/o allergy to MgSo4 and /or Ketamine.
More than 2 attempts at laryngoscopy & intubation.
Procedures necessitating Nasogastric tube insertion.
Laproscopic procedures (prolonged) involving higher airway pressures of >30cmH2O.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in the incidence and severity of Postoperative sore throat by preoperative nebulization of Magnesium sulphate 300mg or Ketamine 50mg	Postoperatively at 0 2 4 12 and 24 hours

Secondary Outcome Measures

Name	Time	Method
Change in the incidence & severity of	Postoperative Dysphagia .

Trial Locations

Locations (1): M S Ramaiah Hospital
🇮🇳
Mysore, KARNATAKA, India
M S Ramaiah Hospital
🇮🇳Mysore, KARNATAKA, India
Archana H P
Principal investigator
7353870570
archanahp4u@gmail.com