comparison of effect of magnesium sulphate nebulization and ketamine nebulization in prevention of postoperative sore throat
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- Change in the incidence and severity of Postoperative sore throat by preoperative nebulization of Magnesium sulphate 300mg or Ketamine 50mg
研究概览
简要总结
A Prospective randomized double blind study titled “Comparison of effect of Magnesium
Sulphate Nebulization and Ketamine nebulization in prevention of postoperative Sore throatâ€
was undertaken at M.S.Ramaiah Hospitals, Bangalore. The study was conducted on 111
patients belonging to ASA 1, 2 and 3 undergoing elective surgery under general anaesthesia
with tracheal intubation. Study subjects were divided into three study groups. Patients in
Group M were nebulized with 3ml (300mg) of Magnesium Sulphate, Group K with 3ml
(50mg) of Ketamine and Group S with 3ml Normal Saline. Nebulization was administered
15minutes prior to the surgery and general anaesthesia was induced 5minutes after
Nebulization. Hemodynamic monitoring was done pre nebulization, post nebulization and
post induction. Postoperatively patients were assessed for incidence and severity of POST,
hoarseness of voice, dysphagia and cough at intervals of 0, 2, 4, 12 and 24 hours
postoperatively.
The incidence of POST was significantly less in Group M (13.5%) and Group K (2.7%) when
compared to Group S (94.6%). There was also significant reduction in the incidence and
severity of Postoperative hoarseness, dysphagia and cough at 0, 2 and 4 hours in Group M
and Group K when compared to Group S.
Thus it can be concluded that Preoperative Nebulization with Magnesium sulphate 300mg or
Ketamine 50mg is an effective method for preventing Postoperative Sore throat,
hoarseness, dysphagia and cough in patients undergoing elective surgery under General
anaesthesia with tracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients giving informed written consent
- •ASA physical status I-III.
- •Malampati Grade I-II.
- •Patients scheduled for elective surgery under GA with Tracheal intubation.
排除标准
- •Surgical procedures of >2hours(H) duration & ENT surgeries on the adenoids, Tonsils & Ear and Intra-Oral surgeries.
- •Prone positions or steep trendelenberg or Anti-Trendelenberg Position.
- •H/o URTI in the previous 2 weeks.
- •H/o Smoking .
- •H/o reactive airway disease & already on bronchodilator nebulization.
- •Endotracheal (ET) Tube cuff pressure >25 cmH2O in order to obtain airtight seal.
- •H/o allergy to MgSo4 and /or Ketamine.
- •More than 2 attempts at laryngoscopy & intubation.
- •Procedures necessitating Nasogastric tube insertion.
- •Laproscopic procedures (prolonged) involving higher airway pressures of >30cmH2O.
结局指标
主要结局
Change in the incidence and severity of Postoperative sore throat by preoperative nebulization of Magnesium sulphate 300mg or Ketamine 50mg
时间窗: Postoperatively at 0 2 4 12 and 24 hours
次要结局
- Change in the incidence & severity of(Postoperative Dysphagia .)