Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation

Not Applicable

• Conditions: Coronary Disease
• Interventions: Behavioral: Usual Text Messages; Behavioral: Personalized Reminders; Behavioral: Interactive Responses

• Registration Number: NCT03732066
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

Few studies have attempt to improve DAPT adherence through social media. The investigators will explore the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among patients requiring DAPT following DES implantation.

Detailed Description

Dual antiplatelet therapy (DAPT) is frequently discontinued after drug-eluting stent (DES) implantation, which could lead to many major adverse cardiovascular events (MACEs). Social media have been proven effective in improving lifestyles and blood pressures control, but few studies have attempt to improve DAPT adherence through social media.Therefore, eligible patients will be enrolled through scanning QR code and randomized in a 1:1 ratio to an intervention group or control group with 12 months of follow-up.The investigators will find out the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among patients requiring DAPT following DES implantation..

Study Timeline

• Study First Submitted: 2018-11-04
• Study First Submitted QC: 2018-11-04
• Study First Posted: 2018-11-06
• Study Start: 2019-01-14
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-23
• Last Update Posted: 2020-08-26
• Primary Completion: 2021-03-30
• Study Completion: 2021-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 760

Inclusion Criteria

• aged ≥18 years
• diagnosed CHD and underwent DES implantation
• provide written informed consent

Exclusion Criteria

• pregnancy
• malignant tumor or end-stage disease with a life expectancy of <1 year;
• refusal to use social media
• refusal to provide written informed consent for this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention Group	Interactive Responses	The intervention group will receive usual text messages, personalized reminders and interactive responses.
Intervention Group	Usual Text Messages	The intervention group will receive usual text messages, personalized reminders and interactive responses.
Intervention Group	Personalized Reminders	The intervention group will receive usual text messages, personalized reminders and interactive responses.
Control Group	Usual Text Messages	The control group will receive usual text messages only.

Primary Outcome Measures

Name	Time	Method
Rate of Discontinuation of Dual Antiplatelet Drug	1 year	Defined as discontinuation of any dual antiplatelet drug owing to patients' own discretion, including bleeding or non-compliance rather than doctors' advice. Changing of DAPT medication between ticagrelor and clopidogrel under doctors' advice will not be identified as dual antiplatelet drug discontinuation; changing of such under own discretion will be identified as such

Secondary Outcome Measures

Name	Time	Method
Medication Adherence	1 year	Dual antiplatelet therapy (DAPT) adherence according to proportion of days covered (PDC) by prescription.
Number of Participants with Major Adverse Cardiovascular Events	1 year	All-cause mortality,target vessel revascularization, non-fatal myocardial infarction, and stroke

Trial Locations

Locations (1)

Guangdong General Hospital; 🇨🇳 Guangzhou, Guangdong, China