Effects of upper body exercise training and beetroot juice on blood pressure

Not Applicable

Completed

• Conditions: Effect of beetroot juice and handgrip training on blood pressure in older adults who are overweight or obese; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN90266095
• Lead Sponsor: ewcastle University (UK)

Brief Summary

2015 results in: https://www.ncbi.nlm.nih.gov/pubmed/26316026

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-01-16
• Study Completion: 2014-02-02
• Last Update Posted: 30 March 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1. Healthy (with no established diagnosis)
2. Non-smoking men and women aged 55-70 years with a body mass index (BMI) in the range of 25-40 kg/m2.

Exclusion Criteria

1. Current participation in other clinical investigations.
2. Physical disabilities, trauma or surgery which limit mobility and impede physical performance (i.e. not able to comply with the isometric exercise intervention).
3. Vegetarianism (likely to have very high nitrate intake).
4. Aversion to beetroot consumption or inability to comply with the study diet (lack of compliance).
5. High physical activity level (may have BMI in obese range but low fat mass).
6. Weight change more than 3.0 kg in the last 2 months (important influence on systemic metabolism and vascular function).
7. Active cancer and any diagnosis of malignant cancer in the last 5 years (systemic effects on study outcomes).
8. Chronic and acute metabolic and inflammatory conditions interfering with the study outcome (systemic effects on study outcomes). For example, severe hypertension (>180 mmHg/>110), kidney stones, gallstones, skin rashes or rheumatoid arthritis.
9. Previous diagnosis of type 1 or type 2 diabetes treated with insulin and oral hypoglycaemic agents (modification of regulation of intermediate metabolism).
10. Weight loss medications (sibutramine, orlistat, rimonabant) and history of bariatric surgery (weight loss related changes in systemic metabolism).
11. Drugs: corticosteroids, sildenafil, diuretics, laxatives, anticoagulants, antacids, nitrate-derived agents, anti-cholinergic, anti-hypertensive (beta-blockers, calcium antagonists, ACE inhibitors and angiotensin receptor inhibitors) (all drugs have either an effect on NO production or insulin sensitivity via different mechanisms).
12. Subjects on hormonal therapies (oestrogens, thyroxine, progesteron), statins and any other anti-dyslipidaemic agent and psychiatric drugs (antidepressants, sedatives, antipsychotics) will be excluded if dose has been started/changed in the previous six months (make sure that these disorders are under strict control to avoid interference with the study outcomes)
13. Haematological disorders including severe anaemia (Hb < 10mg/dL) (risk for the participant and effects on the study outcomes)
14. Major surgical operations interfering with the study outcomes (systemic effects on study outcomes)
15. Alcohol intake >21 units/week for men and >14 units/week for women
16. Non English speakers or volunteers requiring translators or interpreters (since these services are not available for this study)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. 24-hour blood pressure<br> 2. Endothelial function<br><br> The outcome measures will be evaluated at days 0 and 8 (i.e. before and after 7 days intervention). The primary outcome measure is ambulatory 24-hour blood pressure, which will be evaluated on days 0 and 8.<br>