Does beetroot juice improve walking in people with lung disease and low oxygen levels?

Not Applicable

• Conditions: Patients with lung disease (COPD, interstitial pulmonary fibrosis, pulmonary hypertension) who require ambulatory oxygen because of exertional desaturation and adults with a history of COVID-19 and persisting breathlessness at least 3 months following the acute illness and evidence of pulmonary vascular abnormalities; Respiratory

• Registration Number: ISRCTN14888729
• Lead Sponsor: Imperial College

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34853156/ Results for COPD group (added 03/12/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-07-14
• Last Update Posted: 2 August 2023
• Study Completion: 2024-07-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Current inclusion criteria as of 18/07/2023:
1. Adult patients with GOLD I-IV COPD who require ambulatory oxygen because of exertional desaturation
2. Adult patients with IPF who require ambulatory oxygen because of exertional desaturation
3. Adult patients with pulmonary hypertension who require ambulatory oxygen because of exertional desaturation
4. Adults with a history of COVID-19 and persisting breathlessness at least 3 months following the acute illness and evidence of pulmonary vascular abnormalities (abnormal gas transfer defined as a TLco _____

Previous inclusion criteria as of 11/01/2023:
1. Adult patients with GOLD I-IV COPD who require ambulatory oxygen because of exertional desaturation
2. Adult patients with IPF who require ambulatory oxygen because of exertional desaturation
3. Adult patients with pulmonary hypertension who require ambulatory oxygen because of exertional desaturation
4. Adults with a history of COVID-19 and persisting breathlessness at least 3 months following the acute illness and evidence of pulmonary vascular abnormalities
_____

Previous inclusion criteria:
1. Adult patients with GOLD I-IV COPD who require ambulatory oxygen because of exertional desaturation
2. Adult patients with IPF who require ambulatory oxygen because of exertional desaturation
3. Adult patients with pulmonary hypertension who require ambulatory oxygen because of exertional desaturation

Exclusion Criteria

1. Clinically unstable patients (within one month of exacerbation)
2. Significant comorbidity limiting exercise tolerance
3. Significant renal impairment (estimated glomerular filtration rate (eGFR) <50 ml.min-1)
4. Hypotension (systolic blood pressure <100 mmHg)
5. Pregnancy
6. Use of nitrate based medication or PDE5 inhibitors such as sildenafil

Study & Design

• Study Type: Interventional
• Study Design: Not specified