Effect of dexmedetomidine on patients undergoing aneurysm clipping
Not Applicable
- Conditions
- Health Condition 1: I60- Nontraumatic subarachnoid hemorrhage
- Registration Number
- CTRI/2023/05/053066
- Lead Sponsor
- AIIMS, New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All ASA 1/II patients who report within 5 days of ictus and provide informed written consent.
Exclusion Criteria
Refusal of consent, ASA grade III-V, History of prior cerebrovascular accident and Pregnant patient
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect on level of serum level of oxidative stress associated markers (superoxide dismutase, Glutathione peroxidase, Glutathione S-transferase, Malondialdehyde and t ROS) before and after surgery.Timepoint: 1.Before induction of anesthesia <br/ ><br>2 Immediate postoperative period and <br/ ><br>3 48 hrs after surgery
- Secondary Outcome Measures
Name Time Method 1.Change in level of serum level of cytokines (IL-1β, IL-6, IL-17, IL-33 and TNF-α; IL-10 and TGF-beta) before and after surgery. <br/ ><br>2.Change in level of immune cells (neutrophil subsets, T cells, monocytes) before and after surgery. <br/ ><br>3.Change in level of serum level of epinephrine/norepinephrine before and after surgery.Timepoint: 1. Before induction of anesthesia <br/ ><br>2. Immediate postoperative period and <br/ ><br>3. 48 hrs after surgery