Early lung changes on ultrasound in severe pre-eclampsia

Not Applicable

Conditions: Health Condition 1: null- pre-eclamptic parturients with severe features

Registration Number: CTRI/2018/01/011473

Lead Sponsor: PGIMER

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Preeclamptic patients with period of gestation >20 weeks will be assessed for eligibility for

enrollment to the study if they show any one of the following features.11

•BP is >=160 mmHg systolic and/or >=110 mmHg diastolic (on 2 occasions at least 4 hours

apart, while the patient is on bed rest) after 20 weeks gestation

Â¥New onset BP is >=140mmHg systolic and/or >=90mmHg diastolic (on 2 occasions at least 4 hours apart, while the patient is on bed rest) with any of the following is present:

Â¥Pulmonary features

Â¥Thrombocytopenia, platelets count <100,000/uL

Â¥Serum creatinine >=1.1 mg/L or a doubling of the serum creatinine concentration in the absence of other renal disease

Â¥Impaired liver function, elevated blood concentrations of liver transaminases to twice normal concentration

Â¥Cerebral or visual disturbances

Exclusion Criteria

Â¥Pregnancy with severe anaemia

Â¥Gestational/chronic hypertension

Â¥Pregnancy with known cardiac diseases

Â¥Those who are not willing to give consent for participating in the study.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the ability of bedside lung ultrasound to detect interstitial alveolar syndrome in preeclamptic women with severe features admitted for delivery.Timepoint: at admission, before delivery and within 24 hours after delivery

Secondary Outcome Measures

Name	Time	Method
The secondary objectives will include association ,if any, with <br/ ><br>1. Clinical features of acute breathlessness, tachypnea, respiratory compromise <br/ ><br>2. Rapidity of rise in blood pressure over preceding week <br/ ><br>3. Change in biochemical parameters <br/ ><br>4. Any other secondary features having multisystem involvement <br/ ><br>5. To correlate echocardiography finding with lung sonography B-lines (To rule out cardiac diseases) <br/ ><br>Timepoint: during admission period