Functional MRI and Doppler ultrasound of living kidney donors and recipients: a longitudinal trajectory from donor to recipient

Recruiting

Conditions: ier Transplantatie
10038430
Transplant failure
10038365
Transplant function

Registration Number: NL-OMON51682

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Be part of a matched pair of living kidney donors and recipients;
Transplantation and follow-up consult performed at UMCG;
18-75 years old.

Exclusion Criteria

Subjects aged <18 years;
Subjects unable or not willing to provide informed consent;
Subjects with a contraindication for fMRI (e.g. claustrophobia) and/or a DUS.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Functional MRI (fMRI)<br /><br>(P) ASL: % Renal Blood Flow (ml/min/100g)<br /><br>DWI-IVIM: Molecular diffusion (Dslow, mm2/s), Microperfusion (Dfast, mm2/s),<br /><br>Fraction of microperfusion (ffast, %), Apparent diffusion coefficient (ADC,<br /><br>mm2/s)<br /><br>DKI: Diffusional Kurtosis (DK), Diffusion coefficient (mm2/s)<br /><br>DTI: Fractional Anisotropy (FA), Trace (tr), Mean diffusivity (MD, mm2/s)<br /><br>BOLD: Relaxation rate (R2, s-1)<br /><br>TMRE: shear wave speed (m/s), viscosity (rad)<br /><br><br /><br>Doppler Ultrasound (DUS)<br /><br>*% Resistive Index (RI)<br /><br>Grayscale Median (GSM)<br /><br>Shear wave elastography (SWE, kPa)<br /><br>Microbubble (CEUS) Contrast Enhanced Ultrasound (Peak, TP, AUC, MTT)<br /><br>Corticomedullary Differentiation (CMD)<br /><br>Volume (ml)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The measured and/or estimated glomerular filtration rate.<br /><br>Kidney biopsy histology (when available/clinically indicated).<br /><br>Prognostic/Follow up parameters (Duration of admission, postoperative<br /><br>complications, surgical reintervention, delayed graft function (DGF), graft<br /><br>failure, postoperative dialysis, renal function at 1 week, 3 and 6 months and 1<br /><br>year post-transplant, patient survival).</p><br>