Atypical parkinsonism: Early diagnosis with quantitative MRI

Recruiting

• Conditions: Atypical parkinsonism; Parkinson's disease; 10007951

• Registration Number: NL-OMON52291
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 55

Inclusion Criteria

Patients:
- Patients who present at the outpatient clinic of the department of neurology
with symptoms consistent with degenerative parkinsonism.
- For possible PD patients: Diagnosis of Parkinson*s disease is unclear and an
atypical form of parkinsonism is suspected.
- For near-certain PD patients: Patients for whom Parkinson*s disease is highly
suspected.
- At least 50 years old
- Signed informed consent.

Healthy volunteers:
- Healthy subject (defined as a volunteer without and signs or symptoms of
disease)
- At least 50 years old and not older than 75
- Signed informed consent

Exclusion Criteria

- Patients with parkinsonism symptoms caused by medication or essential
tremors.
In addition, both patients and healthy volunteers are excluded if they meet any
of the following criteria:
- a history of another neurodegenerative disease.
- History of significant intracranial disease
- Contra-indication to an MRI exam
- Metal implants
- Women who are pregnant or lactating
- Having any physical or mental status that interferes with the informed
consent procedure

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified