The Effect of Prednisone on Physical Exercise in COPD Patients

Phase 4

Completed

• Conditions: Exercise Performance in Copd Patients
• Interventions: Drug: prednisone

• Registration Number: NCT01978665
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The objective of this study is to investigate if there is an effect on exercise performance og of the anti inflammatory drugs prednisone and solu-medrol in patints with chronic obstructive pulmonary disease(COPD)

Detailed Description

RCT study with 4 days of steroid

Study Timeline

• Study Start: 2013-04
• Status Verified: 2013-11
• Study First Submitted: 2013-11-01
• Study First Submitted QC: 2013-11-06
• Study First Posted: 2013-11-07
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Last Update Submitted: 2020-01-31
• Last Update Posted: 2020-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 14

Inclusion Criteria

FEV1< 60% FEV1/FVC ratio <70 %

• able to use a ergometer bike

Exclusion Criteria

Haemodynamicaly unstable heart conditions

• exacerbations before 6 week entry of the study exacerbation during the study period treatment with beta blockers malignancy the last 5 years allergi toward IMP

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
solumedrol	prednisone	placebo versus solu medrol
placebo	prednisone	measurement of fitness
prednisone and Solumedrol	prednisone	placebo arm versus prednisone

Primary Outcome Measures

Name	Time	Method
effect on muscle power	jan 2013 to july 2013 (6 months)	muscular strenght

Secondary Outcome Measures

Name	Time	Method
the inflammatory response	jan 2013 to july 2013 (6 months)	hsCRP

Trial Locations

Locations (1)

Bispebjerg Hospital; 🇩🇰 Copenhagen, NV, Denmark