Effect of N-acetylcysteine on hydrogen sulfide in chronic kidney disease

Phase 3

Completed

• Conditions: chronic kidney disease; 10038430

• Registration Number: NL-OMON36609
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

Healthy volunteers:
- Adult (> 18 years and older)
- Healthy, as assessed by medical history, blood pressure, plasma
creatinine, and urine dipstick
- No medication use, non-smoking

CKD patient:
- Adult (> 18 years and older)
- CKD stage 3-4 (GFR 15-60 ml/min);Hemodialysis patient:
- Adult (> 18 years and older)
- Hemodialysis patient;Peritoneal dialysis patients
- Adult (> 18 years and older)
- Peritoneal dialysis patient

Exclusion Criteria

Unable to give informed consent
Hypersensitivity to N-acetylcysteine
Pregnancy
Untreated peptic ulcus

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>H2S levels in plasma.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Oxidative stress markers:<br /><br>- thiobarbituric acid reactive substances (TBARS)<br /><br>- superoxide dismutase (SOD)<br /><br>- glutathione peroxidase (GPx)<br /><br>- oxidized low-density lipoprotein (ox-LDL)<br /><br><br /><br>Inflammation markers:<br /><br>- high-sensitivity C-reactive protein (hs-CRP)<br /><br>- interleukin-6 (IL-6)<br /><br>- connective tissue growth factor (CTGF)<br /><br><br /><br>Endothelial cell markers:<br /><br>- intracellular adhesion molecule 1 (ICAM-1)<br /><br>- E-selectin<br /><br>- vascular cell adhesion molecule 1 (VCAM-1)</p><br>