Pharmacokinetic interaction between high dose catechin-contained green tea and midazolam
Not Applicable
- Conditions
- Healthy volunteers
- Registration Number
- JPRN-UMIN000006067
- Lead Sponsor
- Hamamatsu University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
Smoker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pharmacokinetics of midazolam and 1'-hydroxy midazolam
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which catechins in green tea interact with midazolam metabolism in healthy volunteers?
How does high-dose green tea catechin administration affect CYP3A4 enzyme activity and midazolam pharmacokinetics?
Are there specific biomarkers that correlate with altered midazolam clearance during green tea supplementation?
What adverse events are associated with concurrent use of high-dose green tea catechins and benzodiazepines like midazolam?
How do the pharmacokinetic interactions observed in JPRN-UMIN000006067 compare to other herbal-drug interactions involving CYP enzymes?