Identification in Obese Patients of the Mechanism Involved in Intramuscular Lipid Accumulation

Not Applicable

Completed

• Conditions: Obesity; Insulin Resistance; Hyperlipidemia
• Interventions: Other: Lipid accumulation analysis

• Registration Number: NCT01644942
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.

Detailed Description

Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.

Study Timeline

• Study Start: 2008-05
• Study First Submitted: 2012-07-17
• Study First Submitted QC: 2012-07-17
• Study First Posted: 2012-07-19
• Status Verified: 2013-06
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Last Update Submitted: 2013-06-17
• Last Update Posted: 2013-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 33

Inclusion Criteria

• Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2
• Patients who do not practice physical exercise (Voorips index < 9)
• Age between 40 and 70 years- Male gender
• Fast blood glucose <1,10 g/l and no hypoglycemic treatment
• Signed informed consent
• Social security affiliation
• Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen
• Normal biological tests
• Non smoking persons

Exclusion Criteria

• Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests
• Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory.
• Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy
• Allergy to local anaesthetic

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Insulin sensitive patients	Lipid accumulation analysis	-
Insulin resistant patients	Lipid accumulation analysis	-

Primary Outcome Measures

Name	Time	Method
lipid accumulation in skeletal muscle	1 month

Secondary Outcome Measures

Name	Time	Method
lipid accumulation in myotubes from obese patients	1 month

Trial Locations

Locations (1)

CHRU Montpellier; 🇫🇷 Montpellier, France