Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly
Completed
- Conditions
- Acromegaly
- Registration Number
- NCT01819883
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Ages 18 - 75 yr (both groups)
- Study subjects with active acromegaly
- Healthy controls
Exclusion Criteria
- Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer.
- Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus.
- Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers.
- Pregnant women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in Liver Fat Baseline and 3-month follow-up visit Change in intrahepatic fat after biochemical control of acromegaly
Change in Thigh Muscle Cross-sectional Area Baseline and 3-month follow-up visit Change in thigh muscle cross-sectional area after biochemical control of acromegaly
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States