Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native Joint

• Conditions: Arthritis, Septic

• Registration Number: NCT05531227
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Acute septic arthritis is a rare but life-threatening and functionally serious disease. The improvement or disappearance of pain and functional recovery are sometimes difficult to obtain, with in some cases the persistence of synovitis due to a prolonged local inflammatory response, despite early and effective treatment. The consequences are significant for patients with often significant chronic pain, repercussions on autonomy and/or profession. An unfavorable evolution with joint destruction and need for replacement by a prosthesis is not uncommon.

Corticosteroid therapy is widely used in rheumatology in similar tables, for the purpose of drug synovectomy, with good results. The risk of infection remains the main contraindication to its use.

There are very few studies on its use in septic arthritis, either fundamentally or in humans, for which there are no data in adults. However, these have shown results encouraging the investigators not to neglect this therapy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-06
• Study First Submitted: 2022-06-08
• Study Start: 2022-06-20
• Study First Submitted QC: 2022-09-05
• Study First Posted: 2022-09-07
• Last Update Submitted: 2023-05-10
• Last Update Posted: 2023-05-11
• Primary Completion: 2023-12-13
• Study Completion: 2023-12-13

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Complete regression of the pain in a fast way	6 months after treatment with corticosteroids

Trial Locations

Locations (1)

Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France; 🇫🇷 Strasbourg, France