Characterisation of Circadian Rhythm in Autistic Spectrum Disorder : a Clinical, Biochemical and Genetic Study

Assistance Publique - Hôpitaux de Paris1 site in 1 country42 target enrollmentOctober 2009

ConditionsAutistic Disorder

Overview

Phase: N/A
Intervention: Not specified
Conditions: Autistic Disorder
Sponsor: Assistance Publique - Hôpitaux de Paris
Enrollment: 42
Locations: 1
Primary Endpoint: Urinary sulfatoxymelatonin secretion
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.

Registry

clinicaltrials.gov

Start Date

October 2009

End Date

August 2013

Last Updated

11 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Assistance Publique - Hôpitaux de Paris

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients with autistic spectrum disorders
•At least 6 years old
•Membership of a social security scheme
•Informed consent signed by the patient or both holders of parental authority if the subject is a minor, or by a guardian if the subject is under guardianship

Exclusion Criteria

•Recent sleep symptoms
•Incapacity to keep rested for 24 hours

Outcomes

Primary Outcomes

Urinary sulfatoxymelatonin secretion

Time Frame: The determination will be performed at 21 days ( adults)

Secondary Outcomes

Core body temperature rhythm(The determination will be performed at 5 days (adult))
Circadian rhythms assessed with actometer(The determination will be performed at 14 ( child) and 21 days (adult))