NCT01984944已完成不适用
Characterisation of Circadian Rhythm in Autistic Spectrum Disorder : a Clinical, Biochemical and Genetic Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Urinary sulfatoxymelatonin secretion
研究概览
简要总结
Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with autistic spectrum disorders
- •At least 6 years old
- •Membership of a social security scheme
- •Informed consent signed by the patient or both holders of parental authority if the subject is a minor, or by a guardian if the subject is under guardianship
排除标准
- •Recent sleep symptoms
- •Incapacity to keep rested for 24 hours
结局指标
主要结局
Urinary sulfatoxymelatonin secretion
时间窗: The determination will be performed at 21 days ( adults)
次要结局
- Core body temperature rhythm(The determination will be performed at 5 days (adult))
- Circadian rhythms assessed with actometer(The determination will be performed at 14 ( child) and 21 days (adult))
研究者
研究点 (2)
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