Cardiovascular Risk in Sedentary Elderly During Prolonged Sitting Time Versus Intermittent Sitting Time
- Conditions
- Sedentary Lifestyle
- Interventions
- Other: PST+Moderate intensity Long bouts PAOther: Prolonged sitting timeOther: PST+Light intensity Short bouts PAOther: PST+Moderate intensity Short bouts PA
- Registration Number
- NCT02894099
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
In adults, the sedentary behavior was related to cardiovascular risk markers, regardless of the level of physical activity (PA). However, the interruption of prolonged sedentary time has shown positive results even when performed in breaks of low intensity and short duration of activity. The aim of this study is to analyze the influence of a sedentary uninterrupted period, as well as different forms of breaks in sedentary time for the glycemic, insulin and inflammatory markers responses in older adults. This is a controlled clinical trial to be conducted in older (≥ 65 years) and sedentary (\<150 min / week of moderate to vigorous physical activity) people. Those with BMI ≥ to 35.00 kg /m2; diabetic, on medication for glycemic control, or with absolute or relative contraindications to PA practice will not be included . Participants will undergo four phases of intervention separated by an interval of 7 days: (1) Prolonged Sitting Time(PST), in which older people will stay for 5 hours seated; (2) Prolonged sitting with PA of light intensity and short duration (LiSd), time sitting is interrupted for PA bouts of 50-60% of the Heart Rate (HR)max; (3) Prolonged sitting with PA of moderate intensity and short duration (MiSd), time sitting will be interrupted for PA bouts of 65-75% predicted HR max; (4) Prolonged sitting with PA of moderate intensity and long duration (MiLd,) time sitting will be interrupted with PA bouts of 65-75% of HRmax. PA bouts will be performed by walking into a hallway every 20 minutes of sitting time and will last 2 minutes, except in MiLd phase (10 minute breaks every 75 minutes). To evaluate the effects of different PA interruptions in plasma glucose, serum insulin and inflammatory markers, blood samples will be collected serially (-30min, Baseline and 30min, 1h, 2h, 3h, 4h and 5h after a standardized meal. It is expect that interruption of sedentary time, even with breaks of short duration and light intensity can bring benefits to cardiovascular risk markers even in the elderly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 16
- Sedentary older women according World Health Organization, defined as not performing moderate to vigorous physical activity and vigorous for 150 min / week for at least 3 months;
- BMI <to 35.00 kg / m2;
- Sign the Informed Consent.
- Previous diagnosis of Diabetes Mellitus;
- Use of any medication for glycemic control;
- Orthopedic problems that impair walking or use of orthoses for walking.
- Relative or absolute contraindications to perform physical activity.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PST+Moderate intensity Long bouts PA PST+Moderate intensity Long bouts PA Sitting prolonged interrupted with breaks of 10 minutes of moderate physical activity Prolonged Sitting Time (PST) Prolonged sitting time Uninterrupted sitting time of 5 hours PST+Light intensity Short bouts PA PST+Light intensity Short bouts PA Sitting prolonged interrupted with breaks of 2 minutes of light physical activity PST+Moderate intensity Short bouts PA PST+Moderate intensity Short bouts PA Sitting prolonged interrupted with breaks of 2 minutes of moderate physical activity
- Primary Outcome Measures
Name Time Method Change in blood glucose area under curve during 5 hours in four different phases of intervention 4 weeks Assessed by serial blood sampling.The first blood sampling is performed 30 minutes before ingestion of a standard meal mixed solution composed of carbohydrate, fat and protein. The collection of serial blood will be collected in time (-30min, Baseline, 30min, 1h, 2h, 3h, 4h and 5h after the meal). The results will be expressed in mg.dl.
Change in insulin area under curve during 5 hours in four different phases of intervention 4 weeks Assessed by serial blood sampling. The first blood sampling is performed 30 minutes before ingestion of a standard meal mixed solution composed of carbohydrate, fat and protein. The collection of serial blood will be collected in time (-30min, Baseline, 30min, 1h, 2h, 3h, 4h and 5h after the meal).The results will be expressed in µIU/ml.
- Secondary Outcome Measures
Name Time Method Assessment of physical performance 1 day The physical performance will be evaluated by the Short Physical Performance Battery test.
Physical Activity behaviour 7 days use of a tri-axial accelerometer to measure profile of spontaneous physical activity
Assessment of handgrip strength 1 day Measure of handgrip strength with a manual dynamometer (Saehan)
Assessment of muscle strength of knee extensors 1 day Measure of muscle strength of the lower limbs (knee extension) with a isokinetic dynamometer (Biodex 4 Pro)
Change in Inflammatory Cytokines area under curve during 5 hours in four different phases of intervention 4 weeks Assessed by serial blood sampling. The first sampling is performed 30 minutes before ingestion of a standard meal mixed solution composed of carbohydrate, fat and protein. The collection of serial blood will be collected in time (-30min, Baseline, 30min, 1h, 2h, 3h, 4h and 5h after the meal).
Trial Locations
- Locations (1)
Clinics Hospital of the Ribeirao Preto Medical School
🇧🇷Ribeirão Preto, São Paulo, Brazil