To study the effects of steroid injections in fibrosis of oral mucosa using polarising microscope ââ?¬â?? A prospective study
Phase 4
- Conditions
- Health Condition 1: D000- Carcinoma in situ of lip, oral cavity and pharynxHealth Condition 2: K135- Oral submucous fibrosis
- Registration Number
- CTRI/2021/04/032843
- Lead Sponsor
- Govt Dental College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients clinically diagnosed as Grade 2 and Grade 3 Oral submucous fibrosis.
2. Individuals with no underlying systemic disease 3. Individuals ready for the study procedure and who will give written consent to undergo the study willingly .
Exclusion Criteria
1. Patients suffering from systemic conditions such as diabetes, hypertension, bleeding disorders, thyroid disorders
2. Patients allergic to steroids.
3. Patients with trismus but no palpable fibrous bands.
4. Patients unwilling to undergo the study and do not give informed written consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To measure the improvement in clinical mouth opening after intralesional steroidal treatment 2. To check the efficacy of Triamcinolone acetamide with Hyaluronic acid in treatment of oral submucous fibrosis.Timepoint: 9 months
- Secondary Outcome Measures
Name Time Method 1. To investigate the types collagen fibers among different grades of oral submucous fibrosis 2. To compare the difference in pattern of distribution, types and color profile of collagen fibers before and after giving intralesional steroids in oral submucous fibrosis. 3. To compare the effectiveness of picrosirius red stain under polarizing microscopy with routine microscopy for evaluation of the collagen parameters such as types, orientation and color profile.Timepoint: 9 months