Trans Health: Evaluation of Markers of Cardio-metabolic Health and Well-being in Transgender Youth
Completed
- Conditions
- Transgendered Persons
- Registration Number
- NCT02550431
- Lead Sponsor
- University of Colorado, Denver
- Brief Summary
This study plans to learn more about puberty blockers and cross (testosterone and estradiol). There is not much known about how these medications affect hormone levels, heart health and overall general health in young transgender individuals.
- Detailed Description
This study plans to learn more about puberty blockers and cross (testosterone and estradiol). There is not much known about how these medications affect hormone levels, heart health and overall general health in young transgender individuals.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58
Inclusion Criteria
- Followed in Endocrinology Clinic or Adolescent Medicine Clinic at Children's Hospital Colorado
- Between age 9 and 21 years (inclusive)
- Identifies as transgender
- Has been on pubertal blockade or cross-sex hormones for at least three months.
Exclusion Criteria
- Known diabetes
- Presence of significant medical or psychiatric comorbidities
- Using hormones not prescribed by a physician
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Body composition as measured by Dual-energy X-ray absorptiometry (DEXA) in transgender youth compared to age- and BMI-matched controls of both sexes. at enrollment Reproductive hormone concentrations in transgender youth on cross-sex hormones and/or puberty blockers and compared to age-, natal sex- and body mass index (BMI)-matched controls. at enrollment Markers of cardiometabolic risk in transgender youth on cross-sex hormones and/or puberty blockers and compared to age-, natal sex- and BMI-matched controls at enrollment Data on quality of life as measured by the Pediatric Quality of Life Inventory (PedsQL) compared to published norms at enrollment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Hospital Colorado
🇺🇸Aurora, Colorado, United States