Intra Articular Ozone or Hyaluronic Acid Injection: Which One is Superior in Patients with Knee Osteoarthritis? a 6-Month Randomized Clinical Trial

Not Applicable

• Conditions: knee osteoarthritis.; Gonarthrosis [arthrosis of knee]

• Registration Number: IRCT2017041513442N16
• Lead Sponsor: Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 174

Inclusion Criteria

Inclusion Criteria: age between 45-75 years; symptomatic knee OA with the pain aggravated by weight bearing; symptoms lasting for at least 6 months despite conservative treatments; Kellgren-Lawrance radiologic scoring (KLS) system scores ranging from 2-3

Exclusion Criteria

history of trauma, surgery or any invasive procedure in the affected joint during the past 6 months; mal-alignment in lower limbs and abnormal blood count or impaired coagulation tests; pregnant women; patients who were under immunosuppressant treatments; those with an underlying systemic arthropathy (secondary OA); patients being treated with angiotensin converting enzyme inhibitors (ACEI) and significant deficiency in glucose 6-phosphate dehydrogenase (G6PD) level

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee pain. Timepoint: before intervention & 6 months after last intervention. Method of measurement: WOMAC questionnair.

Secondary Outcome Measures

Name	Time	Method
Patient Function. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: before intervention & 6 months after intervention. Method of measurement: VAS.;Joint stiffness. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.