Factors Associated With Success of Non-invasive Positive Pressure Ventilation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Success of NIPPV
研究概览
简要总结
This is a retrospective cohort study to assess the factor associated with success of non-invasive positive ventilation in ALS patients.
详细描述
Patients with ALS who were admitted to a tertiary hospital for initially applying non-invasive positive pressure ventilation (NIPPV). The objective of this study was to investigate factors associated with optimal NIPPV initiation and adherence, and to assess the long-term effects of NIPPV adherence in ALS patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients fulfilling the El Escorial World Federation criteria for probable, or definite ALS
- •Aged ≥ 19 years
- •Patients who performed blood gas analysis including venous blood gas and arterial blood gas before NIPPV application.
排除标准
- •Patients who had experience in applying the NIPPV or currently using NIPPV
- •Patients who applied in outpatient settings
- •Patients who did not perform blood gas analysis before NIPPV application
- •Patietns who had a history of asthma or COPD,
- •Patients who didn't have any record of NIPPV application time
结局指标
主要结局
Success of NIPPV
时间窗: through intervention completion, with an average of 10 days
The success of NIPPV application was defined empirically as use of ≥ 2 hours per day and the failure as use of \< 2 hours for a day or conversion to invasive positive pressure ventilation via tracheostomy or refuse to apply NIPPV during hospitalization.
次要结局
- Lenght of stay(through intervention completion, with an average of 10 days)
研究者
Jaewon Beom
Clinical Associate Professor
Seoul National University Bundang Hospital