Expiratory flow limitation and heliox breathing in resting and exercising chronic obstructive pulmonary disease (COPD) patients
- Conditions
- Chronic obstructive pulmonary disease (COPD)RespiratoryOther chronic obstructive pulmonary disease
- Registration Number
- ISRCTN15098442
- Lead Sponsor
- niversity of Milan (Univrsità degli Studi di Milano) (Italy)
- Brief Summary
2009 results in: https://www.ncbi.nlm.nih.gov/pubmed/19770071 (added 11/07/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 26
1. Stable COPD patients with stable airway obstruction with any level of forced expiratory volume in one second (FEV1) value expressed of predicted
2. Male or female patients, 40 years of age or older
3. Patients must be current or ex-smokers with a smoking history of more than 10 pack years
4. Patients must be to able to perform technical acceptable pulmonary function tests and must be able to perform an incremental exercise test on a cycle ergometer
1. Patients with a signficant disease other than COPD that conditioning a risk for exercise testing (this is evaluated by medical investigators)
2. Patients with a history of asthma
3. Patients with a diagnosis of paroxysmal tachycardia, atrial fibrillation and recent history of myocardial infarction (less of 2 years)
4. Known active tubercolosis
5. History of cystic fibrosis
6. Pregnant women
7. Patients aged more than 85 years old
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the ventilatory response to heliox administration in expiratory flow-limited and non flow-limited COPD patients both at rest and during normal, non-fatiguing physical activities.
- Secondary Outcome Measures
Name Time Method <br> 1. Dyspnoea<br> 2. Flow limitation<br> 3. Forced expiratory volume in one second (FEV1)<br> 4. Inspiratory capacity (IC)<br> 5. Forced volume capacity (FVC)<br>