Oral antihypertensive regimens for management of hypertension in pregnancy
Phase 4
- Conditions
- Health Condition 1: null- Hypertension in pregnancyHealth Condition 2: O268- Other specified pregnancy relatedconditions
- Registration Number
- CTRI/2013/08/003866
- Lead Sponsor
- Gynuity Health Projects
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
•Pregnant gestational age > 28 weeks
•Systolic blood pressure >160 mm Hg OR a diastolic blood pressure of >110 mm Hg measured twice more than 15 minutes apart
•Able to swallow pills
• > 18 years
Exclusion Criteria
•Indication for emergent cesarean or known fetal anomaly
•Anti-hypertensive therapy received in the past 6 hours
•History of eclampsia or other adverse CNS complication (e.g., stroke or PRES) in this pregnancy
•Actively wheezing at time of enrollment or history of asthma complications
•Known coronary artery disease or type I DM with microvascular complications
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Successful outcome will be considered blood pressure that reaches the target (defined as 130-150mmHg systolic and 80-100 mmHg mm Hg diastolic) at 6h without an adverse outcome. Adverse outcomes include hypotension (systolic blood pressure, 120 mm Hg and/or diastolic blood pressure 70 mm Hg and fetal compromise), caesarean section for fetal distress, severe headache and severe headache requiring discontinuation of drug, or eclampsia.Timepoint: Six hours after drug administration
- Secondary Outcome Measures
Name Time Method â?¢the number of hourly BPâ??s in severe rangeTimepoint: every hour after drug administration