Age and performance: the relation between brain structure and cognition - Part II
Completed
- Conditions
- geen aandoeningn.v.t.
- Registration Number
- NL-OMON48809
- Lead Sponsor
- Rijksuniversiteit Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 37
Inclusion Criteria
- Having participated in the study *Age and performance: the relation between brain structure and cognition*.
- Right-handed
- Normal (or corrected to normal) vision
Exclusion Criteria
- Not matching the inclusion criteria
- MR incompatible (possibility of any incompatible metal objects inside the body)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Cognitive measures: Number of words remembered (15 word test), variable<br /><br>representing the Simon effect for inhibition (Simon task), completion time<br /><br>(TMT).<br /><br><br /><br>Imaging measures as derived from MRI scans: Whole brain grey matter volume,<br /><br>cortical thickness in the superior frontal gyrus, FA of the prefrontal cortex</p><br>
- Secondary Outcome Measures
Name Time Method <p>Main study parameters of cognitive performance consist of the default outcome<br /><br>measures of each cognitive task. Regarding the MRI scans we derive volumetric<br /><br>data of grey matter, white matter and cerebral spinal fluid,(mean) cortical<br /><br>thickness, percentage of white matter hyperintensities in relation to brain<br /><br>volume, and DTI scalar values (FA, MD, AD and RD). Standardized change scores<br /><br>of these measures will be calculated.Further more information on reduction of<br /><br>working hours and possible retirement will be taken into consideration. </p><br>