Acute Effects of Sitting and Physical Activity on Brain Health
- Conditions
- Healthy Adults
- Interventions
- Behavioral: Prolonged sitting with simple resistance activitiesBehavioral: Prolonged sitting with social breakBehavioral: Prolonged sitting with walk break
- Registration Number
- NCT04137211
- Lead Sponsor
- The Swedish School of Sport and Health Sciences
- Brief Summary
The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy brain functions, namely cerebral blood flow. It is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day at the office.
- Detailed Description
The study will be a controlled crossover experimental trial with three conditions involving 13 adult participants aged between 40 and 60 years. Each participant will complete each of the three experimental conditions, separated by a washout period of minimum four days. As well, physical activity behaviours and sleep the day/night before the test day will be measured. The first visit will be a familiarization session. On the second, third, and fourth visits, participants will undergo three different standardized 3-hour interventions in a randomized order. Before and immediately after the three-hour interventions, blood pressure, augmentation index, and cerebral hemodynamic response of the prefrontal cortex during standardized cognitive tasks (1,2, and 3-back tests) will be measured. Additionally, saliva samples will be collected the morning of the test day and before and after the interventions, blood glucose will be assessed continuously during the trial, and fitness will be measured at the familiarization visit.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
- Has a BMI under 35kg/m2
- Has diabetes, epilepsy, or circulatory conditions
- Has experienced heart failure, stroke, or myocardial infarction
- Takes treatment for high blood pressure, sleep disorders, depression, or psychosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Prolonged sitting with simple resistance activities Prolonged sitting with simple resistance activities - Prolonged sitting with social break Prolonged sitting with social break - Prolonged sitting with walk break Prolonged sitting with walk break -
- Primary Outcome Measures
Name Time Method Changes in cerebral blood flow before to after 3 hour intervention Oxygenated and deoxygenated hemoglobin concentration changes measured with functional near-infrared spectroscopy
- Secondary Outcome Measures
Name Time Method Augmentation index before to after 3 hour intervention as a measure of arterial stiffness
Blood glucose levels during the 3 hour intervention Cortisol before to after 3 hour intervention Mood before to after 3 hour intervention measured with the Positive and Negative Affect Schedule (PANAS) comprised of 20 affect states (10 positive and 10 negative), each affect state scored on a scale going from 1 (very slightly or not at all) to 5 (extremely)
Sleepiness before to after 3 hour intervention measured with Karolinska Sleepiness Questionnaire; goes from 1 (extremely alert) to 9 (extremely sleepy)
Cognitive performance before to after 3 hour intervention nback cognitive test (time and accuracy)
Alertness before to after 3 hour intervention measured with a Visual Analogue Scale (VAS)
Trial Locations
- Locations (1)
The Swedish School of Sport and Health Sciences (GIH)
🇸🇪Stockholm, Sweden