Comparison of the Effects of Sevoflurane and Midazolam Used for the Maintenance of Anaesthesia on the Levels of Postoperative Cardiac Troponin I in Pediatric Cardiac Surgery

Phase 4

• Conditions: Myocardial Injury; Anaesthetic Preconditioning
• Interventions: Drug: Midazolam; Drug: Sevoflurane

• Registration Number: NCT01548859
• Lead Sponsor: Baskent University

Brief Summary

The purpose of this study is to compare two different anaesthetic agent effect on postoperative Troponin I levels in pediatric cardiac surgery

Detailed Description

Not available

Study Timeline

• Study Start: 2011-07
• Status Verified: 2012-03
• Study First Submitted: 2012-03-06
• Study First Submitted QC: 2012-03-06
• Last Update Submitted: 2012-03-06
• Study First Posted: 2012-03-08
• Last Update Posted: 2012-03-08
• Primary Completion: 2012-06
• Study Completion: 2012-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients scheduled for elective pediatric surgery
• Patients written informed consent for study participation

Exclusion Criteria

• Redo surgery
• History of myocarditis
• Renal failure
• Pulmonary embolism
• Hypothyroidism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Midazolam	Midazolam	Used for maintenance anaesthesia (0.2 mg/kg/saat continuous infusion)
Sevoflurane	Sevoflurane	Used for the maintenance for anaesthesia (% 0.5-8 end tidal concentration)

Primary Outcome Measures

Name	Time	Method
myocardial protective effect of sevoflurane	postoperative 48 hours	Postoperative troponin I levels

Secondary Outcome Measures

Name	Time	Method
Hemodynamic and respiratory data	Postoperative 48 hours	Arterial pressure, heart rate, blood gas analysis, extubation time,

Trial Locations

Locations (1)

Baskent University, Faculty of Medicine; 🇹🇷 Ankara, Çankaya, Turkey