Study of Cardiac PET/CT Imaging to Guide Ablation Treatment of Ventricular Tachycardia
Early Phase 1
Terminated
- Conditions
- Ventricular Tachycardia
- Interventions
- Drug: [C-11] Meta-hydroxyephedrine radioactive tracer (MHED)
- Registration Number
- NCT02962076
- Lead Sponsor
- Khaled Awad, MD
- Brief Summary
Imaging is to be performed prior to procedure using positron emission tomography/ computed tomography (PET/CT), after a special dye is injected. The scans are going to be merged with other cardiac scans when doing the ablation procedure to correlate anatomy with physiology.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- Clinical indication for ventricular tachycardia (VT) ablation (at least one clinical episode of sustained VT) despite antiarrhythmic drug therapy, or if the patient does not wish to be on one
- Ischemic or nonischemic cardiomyopathy
- Sustained monomorphic VT
Exclusion Criteria
- Right ventricular VT
- Polymorphic VT or ventricular fibrillation (VF) being the sole detected clinical arrhythmia
- Patient is unable to sign informed consent
- Recent myocardial infarction less than 30 days
- Recent ablation for ventricular tachycardia less than 30 days
- Patient is unwilling or unable to cooperate with the study
- Prosthetic mitral or aortic valve
- General contraindications to VT ablation, e.g., major contraindication to anticoagulation therapy, known presence of left ventricular thrombus, reversible causes of VT or VF
- General contraindications to PET imaging, e.g., pregnancy or lactation
- General contraindication to magnetic resonance imaging or to the administration of gadolinium.
- Contraindication to the placement of hemodynamic support devices, i.e. the presence of mechanical valves or lack of adequate vascular access
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Single Arm - PET/CT Imaging With [C-11] MHED [C-11] Meta-hydroxyephedrine radioactive tracer (MHED) Single Arm - positron emission tomography/computed tomography imaging with \[C-11\] meta-Hydroxyephedrine tracer
- Primary Outcome Measures
Name Time Method Correlation Between PET Data and Electroanatomic Data 1 week
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mercy Hospital St. Louis
🇺🇸Saint Louis, Missouri, United States