Dexamethasone Vs. Dexmedetomidine for ESPB in Pain Management After Total Knee Arthroplasty
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Sponsor
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- first need of opiate
Study Overview
Brief Summary
Effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for knee arthroplasty
Detailed Description
This study is proposed to explore the effect of perineurial Dexamethasone and Dexmedetomidine on erector spinal plane block duration for spine surgery.
After spine surgery, patients need good analgesia. Peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe.
Local anaesthesia's much lower toxicity threshold makes it essential for its safety. An effective adjuvant, such as Dexamethasone or Dexmedetomidine, could allow for a higher dilution of local anaesthetics while maintaining and enhancing their analgesic effect.
There is considerable research comparing intravenous and perineural dexamethasone and Dexmedetomidine use in orthopaedic surgeries. However, there is a massive lack of research regarding knee surgery and the Erector Spine Plane Block.
In this study, investigators compare perineural Dexamethasone and Dexmedetomidine.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients undergoing primary hip arthroplasty
- •aged >18 years and <100 years
- •ASA physical status 1, 2 or 3.
Exclusion Criteria
- •if they refused to participate,
- •had a history of opioid abuse,
- •had an infection of the site of needle puncture,
- •were less than 18 years of age,
- •were postponed as having ASA 4 or 5,
- •had an allergy to any of the drugs used in the study,
- •renal failure (estimated glomerular filtration rate <15ml/min/1.73m2),
- •liver failure,
- •known or suspected coagulopathy,
- •pre-existing anatomical or neurological disorders in the lower extremities,
- •intellectual disability with problems in pain evaluation,
- •severe psychiatric illness.
Arms & Interventions
Control group
0.2% ropivacaine for erector spinae plane block
Intervention: 0.9% Sodium Chloride Injection (Drug)
Dexamethasone
0.2% ropivacaine + 4mg Dexamethasone for erector spinae plane block
Intervention: Dexamethasone (Drug)
Dexmedetomidine
0.2% ropivacaine + 50ug Dexmedetomidine for erector spinae plane block
Intervention: Dexmedetomidine (Drug)
Outcomes
Primary Outcomes
first need of opiate
Time Frame: 48 hours after surgery
Time after surgery when the patient needs opiate for the first time
Secondary Outcomes
- Opioid consumption(48 hours after surgery)
- Numerical Rating Scale [range 0:10](48 hours after surgery)
- Nerve damage [range 0-4](48 hours after surgery)