Respiratory muscle impairment in patients with Systemic Sclerosis

Recruiting

• Conditions: M34; Systemic sclerosis

• Registration Number: DRKS00003311
• Lead Sponsor: Abteilung Pneumologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Patients:
- Systemic Sclerosis according to the ACR-Criteria
Controls:
- normal lung function

Exclusion Criteria

neuromuscular diseases, thoracic deformity, COPD, respiratory infections, pregnancy, obstructive sleep apnea, cardiac pacemaker, AICD, electric / metal implants in head and neck area

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in TwPmo (twitch mouth pressure) in patients with Systemic Sclerosis compared to healthy subjects.<br>Method: Twitch mouth pressure assessment during bilateral anterior magnetic stimulation of the phrenic nerves (Kabitz et. al Respir Physiol Neurobiol. 2007 Jun 15;156(3):276-82.)

Secondary Outcome Measures

Name	Time	Method
Difference in other parameters of respiratory muscle strength in patients with Systemic Sclerosis compared to healthy subjects (i.e. PImax (maximal inspiratory pressure), SnPna (Sniff Pressure ), P0.1, TwPdi (twitch transdiaphragmatic pressure)).<br>Assessment of these parameters are in accordance with international guidelines (ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624.).