Inspiratory muscle training in patients with nemaline myopathy
Completed
- Conditions
- Nemaline myopathyrod myopathy10028396
- Registration Number
- NL-OMON46630
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 23
Inclusion Criteria
* genetically-confirmed nemaline myopathy
* informed consent from participant or legal representative
Exclusion Criteria
* history of another condition that affects respiratory muscle strength or function (e.g. COPD)*
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome parameter is the change in maximal inspiratory pressure<br /><br>(MIP) after active inspiratory muscle training.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Several secondary outcome parameters:<br /><br>* Diaphragm ultrasound (thickness, thickening, excursion).<br /><br>* Pulmonary function tests (peak cough flow, forced vital capacity, forced<br /><br>expiratory volume the first second, peak expiratory flow, vital capacity)<br /><br>* Respiratory muscle function tests (sniff nasal inspiratory pressure, maximal<br /><br>expiratory pressure, twitch mouth pressure)<br /><br>* Neurological examination<br /><br>* Maximal voluntary contraction<br /><br>* Rate of muscle relaxation<br /><br>* Mobility: Rivermead mobility index, and Community Balance and Mobility Scale<br /><br>* Falls: Falls efficacy scale and Falls History Questionnaire</p><br>