Respiratory muscle training in patients with Spinal Muscular Atrophy
Recruiting
- Conditions
- Spinal AtrophySpinal Muscular Atrophy1002929910010613
- Registration Number
- NL-OMON52847
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
* Patients with SMA aged >= 8 years with respiratory muscle weakness (Maximal
inspiratory pressure < -80 cmH2O) will be invited to participate.
Both patients without respiratory support and patients on night-time
non-invasive ventilatory support are eligible.
* Patients who are treated with Spinraza® for more than 2 months and patients
who are not/or will not be treated with Spinraza® .
Exclusion Criteria
* tracheostomy,
* inability to perform respiratory and/or lung-function testing,
* inability to understand Dutch or English,
* patients who are mentally incompetent,
* patients with a history of pneumothorax or symptomatic low cardiac output
syndrome
* patients who start Spinraza during trial
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method