Childhood Origins of Asthma (COAST)
- Conditions
- AsthmaAllergy
- Registration Number
- NCT00204841
- Lead Sponsor
- University of Wisconsin, Madison
- Brief Summary
Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.
- Detailed Description
No more description necessary.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 287
- children who had one or more parent with a history of allergy or asthma
- pre term infants
- low birth weight infants
- respiratory distress at birth
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate the children longitudinally for the inception and progression of asthma. Birth through age 19 Clinical diagnosis of childhood asthma at age 6 years and older.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Wisconsin
🇺🇸Madison, Wisconsin, United States