Inhibitory Control: Effects of Modulation

Not Applicable

Recruiting

• Conditions: Young Adults
• Interventions: Device: Transcranial direct current stimulation

• Registration Number: NCT04247334
• Lead Sponsor: Butler Hospital

Brief Summary

Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-11-14
• Study First Submitted: 2020-01-24
• Study First Submitted QC: 2020-01-28
• Study First Posted: 2020-01-30
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-05
• Last Update Posted: 2023-12-06
• Primary Completion: 2024-03-01
• Study Completion: 2024-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

1. Low (<1sd below the mean on the BRIEF-Inhibit) or high (>1sd above the mean on BRIEF-Inhibit scale)
2. English fluency to ensure comprehension of study measures and instructions.

Exclusion Criteria

1. Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition)
2. Inability to undergo MRI
3. Current substance abuse disorder
4. Currently prescribed psychiatric medications.
5. Active mania or psychosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Impulsive Participants- Active Stimulation	Transcranial direct current stimulation	Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to active stimulation.
Impulsive Participants- Sham Stimulation	Transcranial direct current stimulation	Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to sham stimulation.

Primary Outcome Measures

Name	Time	Method
fMRI connectivity at rest	2 weeks	Changes in resting state connectivity of the inhibitory control information
fMRI connectivity during a stop signal task	2 weeks	Changes in task-based connectivity on the stop signal task

Trial Locations

Locations (1)

Butler Hospital; 🇺🇸 Providence, Rhode Island, United States