Brain Circuitry of Inhibitory Control: Effects of Modulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Young Adults
- Sponsor
- Butler Hospital
- Enrollment
- 108
- Locations
- 1
- Primary Endpoint
- fMRI connectivity at rest
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Low (\<1sd below the mean on the BRIEF-Inhibit) or high (\>1sd above the mean on BRIEF-Inhibit scale)
- •English fluency to ensure comprehension of study measures and instructions.
Exclusion Criteria
- •Presence of medical conditions contraindicated for tDCS, including history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or women of childbearing age not using effective contraception, or any other serious medical conditions or health problems that would interfere with participation (e.g., skin condition)
- •Inability to undergo MRI
- •Current substance abuse disorder
- •Currently prescribed psychiatric medications.
- •Active mania or psychosis
Outcomes
Primary Outcomes
fMRI connectivity at rest
Time Frame: 2 weeks
Changes in resting state connectivity of the inhibitory control information
fMRI connectivity during a stop signal task
Time Frame: 2 weeks
Changes in task-based connectivity on the stop signal task