euroinflammatory consequences of chronic repetitive head injury in Muay Thai boxing
- Conditions
- n/a10029305
- Registration Number
- NL-OMON37319
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 30
All subjects:
-Age above 18 and below 50 years
-Male sex
-Written informed consent for participation;Boxers only:
-Minimum amount of 20 competitive bouts in Muay Thai boxing with rank A or B
-Minimum amount of 3 training sessions per week
All subjects:
-The use of benzodiazepines.
-The use of anticoagulants or having coagulation disorder.
-Use of somatic medication that may affect the immune system.
-Use of any investigational drug.
-Current or recent (<1 year) alcohol or substance abuse.
-Current or recent (<4 weeks) infectious or inflammatory disease.
-Current systemic disease.
-Major metabolic disease.
-Somatic, organic or neurological disorder (other than mTBI for patients).
-Participation in a scientific research study (<1 year) involving radiation.
-Claustrophobia.
-Presence of materials in the body that can be magnetized.
-Sustained (mild) traumatic brain injury within last 3 months.;For healthy volunteers only:
-Presence of infection of inflammation.
-(History of) Participation in contact sports, such as boxing, Muay Thai boxing, rugby, American football, etc.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameter is the [11C]-PK11195 binding potential in the<br /><br>brain.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters are the degree of cognitive deficits, white<br /><br>matter integrity, perfusion deficits and serum proteins indicative of<br /><br>inflammation.</p><br>