Blood Markers in Periodontal Inflammation and Alzheimer's Disease: A Retrospective Case-Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 3
- 主要终点
- Probing pocket depth
研究概览
简要总结
The aim of this study was to analyse the possible relationship between periodontal inflammation and Alzheimer's disease and to investigate the role of blood parameters in this relationship.
详细描述
This retrospective case-control study will include individuals who were clinically and radiographically examined, diagnosed with periodontal disease, read and signed informed consent forms between March 2022 and July 2025 at the Periodontology Departments of Bezmialem Vakif University, Uskudar University and Bolu Abant Izzet Baysal University Faculty of Dentistry.
In this study, two groups will be formed as a case group consisting of individuals with periodontitis diagnosed with probable Alzheimer's disease according to NINCDS-ADRDA and DSM-V diagnostic criteria and a control group consisting of individuals with periodontitis only.
Patients who underwent periodontal evaluations at six sites per tooth, with the following parameters recorded-plaque percentage, probing pocket depth, percentage of bleeding on probing, clinical attachment level, number of teeth, and periodontal inflamed surface area (PISA)-will be included in the study.
Compliance with the inclusion and exclusion criteria will be verified through patient files and digital records. In individuals with a probable diagnosis of Alzheimer's disease according to NINCDS-ADRDA and DSM-V diagnostic criteria, disease stage as determined by the Clinical Dementia Rating scale and Standardized Mini-Mental Test (SMMT) scores will also be recorded.
Hematological data will be obtained from patients' recorded complete blood count test results and the following parameters will be utilized:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between March 2022 and July 2025, those who applied to the Periodontics Departments of the Dentistry Faculties of Uskudar University, Bezmialem Vakif University and Bolu Abant Izzet Baysal University,
- •Informed consent form was obtained during the examination,
- •Over 50 years of age,
- •Non-smoker and non-alcoholic,
- •No psychiatric disorders affecting cognitive status and no medication affecting cognitive status,
- •Complete blood count was performed within the 6 months prior to the date of inclusion in the study,
- •No dental treatment within the last 1 year,
- •Periodontal examination was performed by expert periodontologists who calibrated the inter- and intra-examination,
- •Individuals diagnosed with periodontitis as a result of periodontal examination and radiographic examination, and
- •For individuals diagnosed with Alzheimer's disease: Recording their stage according to the Clinical Dementia Rating (CDR) and Standardized Mini-Mental Test (SMMT) scores
排除标准
- •Individuals with fewer than 10 teeth,
- •Individuals with uncontrolled systemic disease,
- •Individuals who regularly use anti-inflammatories or corticosteroids
结局指标
主要结局
Probing pocket depth
时间窗: Baseline
Measurement of the depth of a sulcus or periodontal pocket determined by measuring distance from a gingival margin to the base of the sulcus or pocket with a calibrated periodontal probe.
Bleeding on probing (BOP)
时间窗: Baseline
The number obtained by dividing the sum of the positive areas by the sum of the examined areas is multiplied by 100 and the value obtained is expressed as the percentage of bleeding at probing (BOP%).
Periodontal inflammatory surface area (PISA)
时间窗: Baseline
It is the calculation of the area of ulcerated periodontal pockets showing bleeding on probing based on the periodontal epithelial surface area.
次要结局
- Clinical attachment level(Baseline)
- Plaque percentage(Baseline)
- Number of teeth(Baseline)
- White blood cell count(Between baseline and -6th month)
- Neutrophil count(Between baseline and -6th month)
- Lymphocyte count(Between baseline and -6th month)
- Monocyte count(Between baseline and -6th month)
- Eosinophil count(Between baseline and -6th month)
- Basophil count(Between baseline and -6th month)
- Percentage of neutrophils(Between baseline and -6th month)
- Percentage of lymphocytes(Between baseline and -6th month)
- Percentage of monocytes(Between baseline and -6th month)
- Percentage of eosinophils(Between baseline and -6th month)
- Percentage of basophils(Between baseline and -6th month)
- Platelet count (PLT)(Between baseline and -6th month)
- Platelet distribution width (PDW)(Between baseline and -6th month)
- Mean platelet volume (MPV)(Between baseline and -6th month)
- Plateletcrit (PCT)(Between baseline and -6th month)
- Red blood cell count(Between baseline and -6th month)
- Hemoglobin (Hb)(Between baseline and -6th month)
- Hematocrit (HCT)(Between baseline and -6th month)
- Mean corpuscular volume (MCV)(Between baseline and -6th month)
- Mean corpuscular hemoglobin (MCH)(Between baseline and -6th month)
- Mean corpuscular hemoglobin concentration (MCHC)(Between baseline and -6th month)
- Red blood cell distribution width (RDW)(Between baseline and -6th month)
- Neutrophil-to-lymphocyte ratio (NLR)(Between baseline and -6th month)
- Monocyte-to-Lymphocyte Ratio (MLR)(Between baseline and -6th month)
- Platelet-to-lymphocyte ratio (PLR)(Between baseline and -6th month)
- Pan-immune inflammation value (PIV)(Between baseline and -6th month)
- Systemic immune-inflammation index (SII)(Between baseline and -6th month)
- Hemoglobin to erythrocyte ratio (HRR)(Between baseline and -6th month)
- Standardized Mini-Mental Test (SMMT)(Baseline)
- Clinical Dementia Rating Scale(Baseline)
研究者
Kubra Karaduran
Assistant professor
Uskudar University