A Study on Rare Dermatological Infections Conducted at Three Major Reference Hospitals in Costa Rica.

Completed

• Conditions: Blastomycosis; Paracoccidioidomycosis; Phaeomycosis; Sporotrichosis; Chromomycosis; Mycobacterial Cutaneous Infection; Nocardiosis; Coccidioidomycosis; Actinomycosis; Mycetoma

• Registration Number: NCT06523998
• Lead Sponsor: Caja Costarricense de Seguro Social

Brief Summary

In Costa Rica there are some descriptive studies of some of these rare infectious diseases (sporotrichosis, chromomycosis and mycetomas); however, there are no recent published reports. Most of the publications on the subject date back to the previous century; from 2000 to the present year there are only publications of small series of cases, so the current behavior of these skin infections is unknown. The primary objective is to analyze the epidemiological, clinical, and therapeutic profile and determine the risk factors in patients with a diagnosis of rare infections of dermatological interest treated at Hospital México, Hospital Rafael Calderón Guardia, and Hospital San Juan de Dios during the period 2019-2023.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-11
• Primary Completion: 2024-05-24
• Study Completion: 2024-05-24
• Status Verified: 2024-07
• Study First Submitted: 2024-07-23
• Study First Submitted QC: 2024-07-26
• Last Update Submitted: 2024-07-26
• Study First Posted: 2024-07-29
• Last Update Posted: 2024-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 95

Inclusion Criteria

1. Age over 18 years, regardless of gender and ethnic group.
2. Patients who during the period from January 1, 2019 to December 31, 2023 received medical care at the Hospital Rafael Ángel Calderón Guardia, Hospital México and Hospital San Juan de Dios.
3. Subjects who meet a confirmed microbiological, histological and/or molecular diagnosis of sporotrichosis, chromomycosis, actinomycosis, nocardiosis, mycetoma, mycobacterial infection, coccidioidomycosis, blastomycosis, paracoccidioidomycosis, cutaneous nocardiosis and pheomycotic abscess (either through the unique digital health record, pathology registries, clinical laboratory service database of each hospital, clinical laboratory of the University of Costa Rica and Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud).
4. Subjects diagnosed at a private level and referred to continue medical care at Hospital Rafael Ángel Calderón Guardia, Hospital México and Hospital San Juan de Dios.

Exclusion Criteria

1. The research team may exclude patients who have an unconfirmed diagnosis, an erroneous diagnosis, or have participated in the study before, as they may hinder the ability to obtain satisfactory data to achieve the study's objectives.
2. Patients who have more than 30% of the variables required for analysis missing will also be excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine the risk factors	5 year	Analyze the epidemiological, clinical, and therapeutic profile and determine the risk factors in patients with a diagnosis of rare infections of dermatological interest treated at Hospital México, Hospital Rafael Calderón Guardia, and Hospital San Juan de Dios during the period 2019-2023.
Determine the diagnostic methods	5 year	Determine the diagnostic methods utilized for each case, including culture, histological techniques, and molecular testing.
Analyze epidemiological, clinical, and therapeutic profile	5 year	Analyze the epidemiological, clinical, and therapeutic profile and determine the risk factors in patients with a diagnosis of rare infections of dermatological interest treated at Hospital México, Hospital Rafael Calderón Guardia, and Hospital San Juan de Dios during the period 2019-2023.

Trial Locations

Locations (3)

Hospital México; 🇨🇷 San José, Costa Rica

Hospital San Juan de Dios; 🇨🇷 San José, Costa Rica

Hospital Rafael Ángel Calderón Guardia; 🇨🇷 San José, Costa Rica