The Effects of Escitalopram on Cytokines in Depressive Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- The changes in cytokines
研究概览
简要总结
The association of cytokines with escitalopram has not been investigated in patients with major depressive disorder (MDD). Hence, the investigators will examine this association.
详细描述
In addition to serotonin, inflammatory process has been suggested in the development of major depressive disorder (MDD) and in its associated treatment. Escitalopram is an antidepressant that has been widely used in patients with MDD because of the promising results. The association of cytokines with escitalopram has not been investigated in patients with MDD. Hence, the investigators will examine this association.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DSM-IV-defined Major depressive disorder, single episode
- •Hamilton Depression Rating Scale exceeding 14 scores
排除标准
- •Major medical disorders
- •Substance use
- •Allergy to escitalopram
研究组 & 干预措施
Escitalopram
Escitalopram 10 mg/d to 20 mg/d
干预措施: Escitalopram (Drug)
结局指标
主要结局
The changes in cytokines
时间窗: Week 0, Week 4
Hamilton Depression Rating Scale, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17A, G-CSF, GM-CSF, IFN-γ, MCP-1, MIP-1β, TNF-α
次要结局
- The changes in Hamilton Depression Rating Scale(week 0, week 4)