Different Effects of Sevoflurane, Propofol and Combine of Sevoflurane and Propofol Maintained Anesthesia on Peripheral Blood Lymphocytes During Off-pump Coronary Artery Bypass Graft Surgery
Overview
- Phase
- N/A
- Intervention
- Sevoflurane
- Conditions
- Anesthesia
- Sponsor
- Ruijin Hospital
- Enrollment
- 105
- Locations
- 1
- Primary Endpoint
- Lymphocyte Count
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.
Investigators
Li-Jie Jia
resident
Ruijin Hospital
Eligibility Criteria
Inclusion Criteria
- •male adults
- •aged 18-80 yr
- •undergoing elective OPCAB surgery containing left anterior descending artery bypass
Exclusion Criteria
- •a previous unusual response to any of the experimental anesthetics
- •severe cardiac dysrhythmias or ejection fraction below 30%
- •hemodynamic instability
- •previous surgical coronary artery repair
- •anemia, abnormal leukocytes or coagulopathy
- •severe hypertension
- •severe hepatic (albumin\<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions
- •concomitant surgical procedures and psychiatric disorders
- •Insulin-dependent diabetics
Arms & Interventions
Sevoflurane
Intervention: Sevoflurane
Propofol
Intervention: Propofol
Combine of sevoflurane and propofol
Intervention: combine of sevoflurane and propofol
Outcomes
Primary Outcomes
Lymphocyte Count
Time Frame: 1 day after surgery
Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.
Secondary Outcomes
- Intensive Care Unit Staying Days(participants will stay in intensive care unit after surgery, an expected average of 2 days)