The Effects of Propofol and Sevoflurane on Postoperative Heart Rate Variability and Postoperative Nausea Vomiting
Overview
- Phase
- Not Applicable
- Intervention
- Propofol
- Conditions
- Postoperative Nausea and Vomiting
- Sponsor
- Ajou University School of Medicine
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- heart rate variability in recovery room
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Propofol and sevoflurane have different effects on heart rate variability. It has not yet been reported whether this difference in effect remains at recovery time after anesthesia and the difference is related to postoperative nausea and vomiting has not been studied. The aim of this study is observe whether propofol and sevoflurane have different effects on heart rate variability during recovery and the differences can predict the occurrence of postoperative nausea and vomiting.
Detailed Description
Different types of anesthetics have different effects on heart rate variability. However It has not yet been reported whether this difference in effect remains at recovery time after anesthesia. Several studies have been reported that preoperative heart rate variability predicted the occurence of postoperative nausea and vomiting. However, whether the difference in heart rate variability after anesthesia is related to the difference in postoperative nausea and vomiting has not been studied. Therefore, this study aims to observe whether propofol and sevoflurane have differences during recovery period after anesthesia in heart rate variabiliy. In addition, we want to examine that these differences during recovery period in heart rate variability can predict the occurrence of nausea and vomiting within 24 hours after surgery.
Investigators
In-kyong Yi
assistant professor
Ajou University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •Scheduled breast surgery under general anesthesia
Exclusion Criteria
- •Arrhythmia
- •Uncooperative with the measuring heart rate variability
- •Hypertension on medication
- •Patients taking psychiatric drugs
- •Thyroid disease
Arms & Interventions
Propofol
General anesthesia using propofol infusion
Intervention: Propofol
Sevoflurane
General anesthesia using sevoflurane
Intervention: Sevoflurane
Outcomes
Primary Outcomes
heart rate variability in recovery room
Time Frame: within 1 hour
Postoperative heart rate variability measuring at recovery room Frequency domain result: total power, low frequency power, high frequency power, Low frequency/high frequency power ratio
Secondary Outcomes
- Patient's satisfaction about postoperative nausea and vomiting(48 hours after anesthesia)
- Postoperative nausea vomiting impact scale(48 hours after anesthesia)
- The incidence of postoperative nausea and vomiting(48 hours after anesthesia)