Correlation Between Expression of Hormonal Receptors, Clinical Data, and Methylation Profile in Meningiomas (MethylRH-M)
- Conditions
- Meningioma
- Registration Number
- NCT06278103
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
This research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. The underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. The main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. The secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 180
- Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022.
- Patients who did not express their consent to participate in the study.
- Patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study.
- Patients with grade 1 meningiomas not selected by randomization.
- Patients withdrawing their consent.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method immunohistochemical expression of different hormonal receptors up to 24 years after surgery Evaluated on FFPE sections
- Secondary Outcome Measures
Name Time Method methylation profile of the promoters of hormonal receptor genes up to 24 years after surgery Methylation profile established from frozen tissue.