THE ROLE OF mRNA EXPRESSION OF THYMIDILATE SYNTHASE (TS), METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR), AND DIHIDROPYRIMIDIN DEHYDROGENASE (DPD) AS PREDICTORS OF NEOADJUVANT CHEMOTHERAPY RESPONSE OF 5FU REGIMEN IN ADVANCED COLORECTAL CANCER
Completed
- Conditions
- Patients with the colorectal cancer (adenocarcinoma) and was given neoadjuvant chemotherapy with (Capecitabine-Oxaliplatin regimen.Colorectal CancerChemotherapypredictor
- Registration Number
- TCTR20240618004
- Lead Sponsor
- Self funding
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
The participants in this study were stage III and IV colorectal cancer, with histopathological results of adenocarcinoma obtained by biopsy and were willing to receive adjuvant chemotherapy with Capecitabine + Oxaliplatin.
Exclusion Criteria
We excluded damaged tissue sample, drop-out patients from chemotherapy follow-up, and pathology results of signet ring cell carcinoma and mucinous carcinoma.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mRNA Expression DIHIDROPYRIMIDIN DEHYDROGENASE (DPD), THYMIDILATE SYNTHASE (TS), and METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) gene Before and after Chemotherapy Capecitabine + Oxaliplatin. Fold change mRNA expression
- Secondary Outcome Measures
Name Time Method Characteristic data, Tumor size, and carcinoembryonic antigen (CEA) levels When patien admitted to our hospital, Before and after Chemotherapy Capecitabine + Oxaliplatin. age, sex, and colorectal cancer grading, tumor size, and response chemotherapy