We Analyse Metabolites in Dried Blood Spots From Newborns That Later in Life Developed an Eating Disorder.

Active, not recruiting

• Conditions: Eating Disorders

• Registration Number: NCT07016334
• Lead Sponsor: Karolinska Institutet

Brief Summary

Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation.

Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-01
• Status Verified: 2025-05
• Study First Submitted: 2025-05-21
• Study First Submitted QC: 2025-06-03
• Last Update Submitted: 2025-06-03
• Study First Posted: 2025-06-11
• Last Update Posted: 2025-06-11
• Primary Completion: 2026-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• in PKU-register with or withou life-time diagnosis of anorexia or bulimi nervosa

Exclusion Criteria

• not in PKU register

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabolomic factors measured by mass-spectrometry	Sampled at birth (day 1)	Metabolomic factors such as amino acids, sugars, lipids, and organic acids extracted from dried blood spots sampled at birth are measured by mass spectrometry

Trial Locations

Locations (1)

Karolinska Institutet; 🇸🇪 Stockholm, Sweden