A cinical trial to study the effect of yoga intervention as well as standard treatment at genomic level in obese patients
Not Applicable
- Conditions
- Health Condition 1: null- Obese subjects with BMI 25-35 kg/m2Health Condition 2: E660- Obesity due to excess calories
- Registration Number
- CTRI/2016/08/007136
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a.Adults aged between 20 and 45 years
b.Gender Both Male and Female
c.BMI - 25-35 kg/m2
Exclusion Criteria
a)Subjects enrolled in professional/supervised weight reduction program in last 12 months
b)Diabetic patients (Fasting plasma glucose > 126mg/dL)
c)Pregnant women
d)Subjects with inability or with restrictions to participate in a regular physical activity program
e)Subjects with any low grade chronic inflammatory diseases
f)Self- reported/previously diagnosed renal, hepatic & thyroid disorder
g)Subjects on vitamin D supplementation from last 3 months i.e 1000 IU
h)Subjects with heavy alcohol consumption ( >3 drinks/day) and smoking ( >2cigrettes/day)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To quantify the effect of yogaâ??based lifestyle intervention at genetic level by gene expression analysis of TNFα,IL-6, MRPL43, Nuclear factor Erythroid 2 (NFE2) as well as the telomere length and telomerase enzyme activity .Timepoint: 12 weeks
- Secondary Outcome Measures
Name Time Method �Changes in the Vitamin D receptor Gene expression after Yoga based lifestyle intervention <br/ ><br>�Quantification of protein level of TNFα, IL-6, MRPL43, Nuclear factor Erythroid 2 (NFE2. <br/ ><br>Timepoint: 12 weeks