inking protein profiles to disease progression and clinical expression in Parkinson*s disease

Completed

• Conditions: Parkinson's disease; movement disorders; 10028037

• Registration Number: NL-OMON33857
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 282

Inclusion Criteria

PATIENTS
(1) Patients of the outpatient clinic for movement disorders with a suspected parkinsonian syndrome, based upon the presence of at least one of the following parkinsonian symptoms: hypokinesia, bradykinesia, rigidity, tremor or postural instability.
(2) Patients already under treatment at the outpatient clinic for movement disorders and diagnosed with PD or one of the following other parkinsonian syndromes: MSA, PSP, vascular parkinsonism.
(3) Being able to understand the aim of the study and the study procedure and give written informed consent;HEALTHY CONTROLS
Being able to understand the aim of the study and the study procedure and give written informed consent

Exclusion Criteria

PATIENTS
(1) A history of neurological disorders other than a parkinsonian syndrome, that affect the central nervous system or are known to influence CSF proteins
(2) Use of anticoagulants or indications for coagulation disorders
(3) Infected skin over the needle entry side for lumbar puncture
(4) Signs of raised intracranial pressure
(5) Unwillingness to be informed of unexpected medical findings;HEALTHY CONTROLS
(1) A history of neurological disorders that affect the central nervous system or are known to influence CSF proteins
(2) Abnormal findings at general neurological examination
(3) Use of anticoagulants or indications for coagulation disorders
(4) Infected skin over the needle entry side for lumbar puncture
(5) Signs of raised intracranial pressure
(6) Unwillingness to be informed of unexpected medical findings

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified