Associations Between the Cardiovascular Risk Markers and Neuroplasticity in Sedentary or Physically Active Spinal Cord Injured Subjects of the Wheelchair Dancer Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- SCI - Spinal Cord Injury
- Sponsor
- Paracelsus Medical University
- Enrollment
- 54
- Locations
- 2
- Primary Endpoint
- Evaluation of echocardiography results between different study groups
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood markers, echocardiography of the heart and peripheral vessels, as well as blood pressure and arterial stiffness, in subjects performing either wheelchair dancing, wheelchair marathon or no sports. Further, it will be investigated, whether there is an association between neuroplasticity and cardiovascular health, as measured by electroencephalography (EEG), transcranial magnetic stimulation (TMS) and blood levels of the brain-derived neurotrophic factor (BDNF).
We hypothesize that the cardiovascular, physical and psychological benefits of wheelchair dancing and/or wheelchair marathon parallel improved neuroplasticity in SCI-patients
Investigators
Prof. Josef Niebauer M.D., Ph.D., MBA
Prof. Josef Niebauer, M.D., Ph.D, MBA
Paracelsus Medical University
Eligibility Criteria
Inclusion Criteria
- •wheelchair users independent of the cause of the walking impairment, preferably with spinal cord injury.
Exclusion Criteria
- •metallic implanters, additional neurologic pathologies, pregnancy
Outcomes
Primary Outcomes
Evaluation of echocardiography results between different study groups
Time Frame: October 2017- June 2018
Evaluation of echocardiography comparing healthy individuals and patients using wheelchairs (three different groups).
comparison of cardiovascular risk factors between different study groups
Time Frame: October 2017- June 2018
measurement for arterial stiffness parameters, via pulse wave analysis. Comparison between healthy individuals and patients using wheelchairs (three different groups).