Three Dimensional Versus Two Dimensional Echocardiography in Assessment of Severity and Scoring of Rheumatic Mitral Stenosis.

• Conditions: Mitral Valve Stenosis
• Interventions: Other: 2D Echocardiography; Other: 3D Echocardiography

• Registration Number: NCT04968431
• Lead Sponsor: Assiut University

Brief Summary

Although the prevalence of rheumatic fever is decreasing in developed countries, it still affects numerous areas in the non- industrialized world. Untreated mitral stenosis (MS) contributes significantly to global morbidity and mortality. Echocardiography is the main diagnostic imaging modality for evaluation of mitral valve (MV) obstruction and assessment of severity and hemodynamic consequences of MS as well as valve morphology. According to current guidelines and recommendations for clinical practice, the severity of MS should not be defined by a single value but assessed by valve areas, mean Doppler gradients, and pulmonary pressures. Transthoracic echocardiography is usually sufficient to grade MS severity and to define the morphology of the valve. Transesophageal echocardiography is used when the valve cannot be adequately assessed with transthoracic echocardiography and to exclude intracardiac thrombi before a percutaneous or surgical intervention. Three-dimensional transthoracic and transesophageal echocardiographic assessment provide more detailed physiological and morphological information. Current definitive treatment for severe MS involves percutaneous balloon mitral valvuloplasty (PMBV) or surgery. The effectiveness of PMBV is related to the etiology of MS, and certain anatomic characteristics tend to predict a more successful outcome for PMBV, whereas other MV structural findings might suggest balloon valvuloplasty to be less likely successful or even contraindicated. Does 3D echo can add more useful information over 2 D echo that could change treatment decision?

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-06-16
• Status Verified: 2021-07
• Study Start: 2021-07
• Study First Submitted QC: 2021-07-08
• Last Update Submitted: 2021-07-08
• Study First Posted: 2021-07-20
• Last Update Posted: 2021-07-20
• Primary Completion: 2023-07
• Study Completion: 2024-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Patient age range from 18 years to 60 years.
2. Patient with isolated mitral stenosis (except those with mild mitral regurgitation and are candidate for PTMC by 2D Echo evaluation).
3. Patient with normal left ventricular EF
4. patient both in sinus rhythm or atrial fibrillation

Exclusion Criteria

1. Age below 18 years or above 60 years.
2. Patient with another valve lesion or more than mild mitral regurgitation.
3. Patient with impaired cardiac function.
4. Mitral stenosis of other etiology than rheumatic origin

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mitral Stenosis patient	2D Echocardiography	-
Mitral Stenosis patient	3D Echocardiography	-

Primary Outcome Measures

Name	Time	Method
benefit of 3D echocardiography in mitral stenosis severity	1 year	The added benefit of 3D echocardiography over 2D echo in evaluation of rheumatic mitral stenosis severity with pressure gradient
benefit of 3D echocardiography in mitral stenosis scoring	1 year	The added benefit of 3D echocardiography over 2D echo in evaluation of rheumatic mitral stenosis score